%0 Journal Article %1 ramachandran2005support %A Ramachandran, Sohini %A Deshpande, Omkar %A Roseman, Charles C. %A Rosenberg, Noah A. %A Feldman, Marcus W. %A Cavalli-Sforza, L. Luca %D 2005 %J Proceedings of the National Academy of Sciences of the United States of America %K F_ST clines geographic_variation human_genome population_genomics population_structure stepping_stone_models %N 44 %P 15942-15947 %R 10.1073/pnas.0507611102 %T Support from the relationship of genetic and geographic distance in human populations for a serial founder effect originating in Africa %U http://www.pnas.org/content/102/44/15942.abstract %V 102 %X Equilibrium models of isolation by distance predict an increase in genetic differentiation with geographic distance. Here we find a linear relationship between genetic and geographic distance in a worldwide sample of human populations, with major deviations from the fitted line explicable by admixture or extreme isolation. A close relationship is shown to exist between the correlation of geographic distance and genetic differentiation (as measured by F ST) and the geographic pattern of heterozygosity across populations. Considering a worldwide set of geographic locations as possible sources of the human expansion, we find that heterozygosities in the globally distributed populations of the data set are best explained by an expansion originating in Africa and that no geographic origin outside of Africa accounts as well for the observed patterns of genetic diversity. Although the relationship between F ST and geographic distance has been interpreted in the past as the result of an equilibrium model of drift and dispersal, simulation shows that the geographic pattern of heterozygosities in this data set is consistent with a model of a serial founder effect starting at a single origin. Given this serial-founder scenario, the relationship between genetic and geographic distance allows us to derive bounds for the effects of drift and natural selection on human genetic variation.

@article{ramachandran2005support, abstract = {Equilibrium models of isolation by distance predict an increase in genetic differentiation with geographic distance. Here we find a linear relationship between genetic and geographic distance in a worldwide sample of human populations, with major deviations from the fitted line explicable by admixture or extreme isolation. A close relationship is shown to exist between the correlation of geographic distance and genetic differentiation (as measured by F ST) and the geographic pattern of heterozygosity across populations. Considering a worldwide set of geographic locations as possible sources of the human expansion, we find that heterozygosities in the globally distributed populations of the data set are best explained by an expansion originating in Africa and that no geographic origin outside of Africa accounts as well for the observed patterns of genetic diversity. Although the relationship between F ST and geographic distance has been interpreted in the past as the result of an equilibrium model of drift and dispersal, simulation shows that the geographic pattern of heterozygosities in this data set is consistent with a model of a serial founder effect starting at a single origin. Given this serial-founder scenario, the relationship between genetic and geographic distance allows us to derive bounds for the effects of drift and natural selection on human genetic variation.}, added-at = {2011-11-19T19:48:34.000+0100}, author = {Ramachandran, Sohini and Deshpande, Omkar and Roseman, Charles C. and Rosenberg, Noah A. and Feldman, Marcus W. and Cavalli-Sforza, L. Luca}, biburl = {https://www.bibsonomy.org/bibtex/291021920c84a03435e9c32dd0cb03a8b/peter.ralph}, description = {Support from the relationship of genetic and geographic distance in human populations for a serial founder effect originating in Africa}, doi = {10.1073/pnas.0507611102}, eprint = {http://www.pnas.org/content/102/44/15942.full.pdf+html}, interhash = {3ee8c2b4cfbdc2647d15cfcaba794e46}, intrahash = {91021920c84a03435e9c32dd0cb03a8b}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {F_ST clines geographic_variation human_genome population_genomics population_structure stepping_stone_models}, number = 44, pages = {15942-15947}, timestamp = {2011-11-19T19:48:34.000+0100}, title = {Support from the relationship of genetic and geographic distance in human populations for a serial founder effect originating in Africa}, url = {http://www.pnas.org/content/102/44/15942.abstract}, volume = 102, year = 2005 }