%0 Journal Article %1 RN121 %A Parvanova, A. %A Abbate, M. %A Yañez, A. M. %A Bennasar-Veny, M. %A López-González Á, A. %A Ramírez-Manent, J. I. %A Iliev, I. P. %A Fresneda, S. %A Arias-Fernandez, M. %A Remuzzi, G. %A Ruggenenti, P. %D 2023 %J Diabetes Res Clin Pract %K grapp-caib %P 110729 %R 10.1016/j.diabres.2023.110729 %T MAFLD and glomerular hyperfiltration in subjects with prediabetes, visceral obesity and "preserved" kidney function: A cross-sectional study %V 201 %X AIMS: To investigate the prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) in prediabetes, visceral obesity, and preserved kidney function, and explore whether MAFLD is associated with hyperfiltration. METHODS: We analyzed data from 6697 Spanish civil servants, aged 18-65 years, with fasting plasma glucose ≥ 100 and ≤ 125 mg/dL (prediabetes, ADA), waist circumference ≥ 94 cm in men and ≥ 80 cm in women (visceral obesity, IDF) and de-indexed estimated glomerular filtration rate (eGFR) ≥ 60 ml/min, collected during occupational health visits. The association between MAFLD and hyperfiltration (eGFR > age- and sex-specific 95th percentile) was tested by multivariable logistic regression analyses. RESULTS: Overall, 4213 patients (62.9%) had MAFLD, and 330 (4.9%) were hyperfiltering. MAFLD was more frequent in hyperfiltering than in non-hyperfiltering subjects (86.4% vs 61.7%, P < 0.001). BMI, waist circumference, systolic, diastolic, mean arterial pressure, and prevalence of hypertension were higher in hyperfiltering than in non-hyperfiltering subjects (P < 0.05). MAFLD was independently associated with hyperfiltration, even after adjusting for common confounders OR (95% CI): 3.36 (2.33-4.84), P < 0.001. In stratified analyses MAFLD potentiated age-related eGFR decline vs. non-MAFLD (P < 0.001). CONCLUSIONS: More than half of subjects with prediabetes, visceral obesity and eGFR ≥ 60 ml/min presented MAFLD that was associated with hyperfiltration and potentiated the age-related eGFR decline.

@article{RN121, abstract = {AIMS: To investigate the prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) in prediabetes, visceral obesity, and preserved kidney function, and explore whether MAFLD is associated with hyperfiltration. METHODS: We analyzed data from 6697 Spanish civil servants, aged 18-65 years, with fasting plasma glucose ≥ 100 and ≤ 125 mg/dL (prediabetes, ADA), waist circumference ≥ 94 cm in men and ≥ 80 cm in women (visceral obesity, IDF) and de-indexed estimated glomerular filtration rate (eGFR) ≥ 60 ml/min, collected during occupational health visits. The association between MAFLD and hyperfiltration (eGFR > age- and sex-specific 95th percentile) was tested by multivariable logistic regression analyses. RESULTS: Overall, 4213 patients (62.9%) had MAFLD, and 330 (4.9%) were hyperfiltering. MAFLD was more frequent in hyperfiltering than in non-hyperfiltering subjects (86.4% vs 61.7%, P < 0.001). BMI, waist circumference, systolic, diastolic, mean arterial pressure, and prevalence of hypertension were higher in hyperfiltering than in non-hyperfiltering subjects (P < 0.05). MAFLD was independently associated with hyperfiltration, even after adjusting for common confounders [OR (95% CI): 3.36 (2.33-4.84), P < 0.001]. In stratified analyses MAFLD potentiated age-related eGFR decline vs. non-MAFLD (P < 0.001). CONCLUSIONS: More than half of subjects with prediabetes, visceral obesity and eGFR ≥ 60 ml/min presented MAFLD that was associated with hyperfiltration and potentiated the age-related eGFR decline.}, added-at = {2023-05-29T06:58:05.000+0200}, author = {Parvanova, A. and Abbate, M. and Yañez, A. M. and Bennasar-Veny, M. and López-González Á, A. and Ramírez-Manent, J. I. and Iliev, I. P. and Fresneda, S. and Arias-Fernandez, M. and Remuzzi, G. and Ruggenenti, P.}, biburl = {https://www.bibsonomy.org/bibtex/29287d4374c1045e63c614bd08108bd29/nachoricci}, doi = {10.1016/j.diabres.2023.110729}, interhash = {3fe1d73cb8b9d61b67753c640537cabc}, intrahash = {9287d4374c1045e63c614bd08108bd29}, issn = {0168-8227}, journal = {Diabetes Res Clin Pract}, keywords = {grapp-caib}, pages = 110729, timestamp = {2023-05-29T06:58:41.000+0200}, title = {MAFLD and glomerular hyperfiltration in subjects with prediabetes, visceral obesity and "preserved" kidney function: A cross-sectional study}, type = {Journal Article}, volume = 201, year = 2023 }