%0 Journal Article %1 kaladhar2021methylation %A Kaladhar, Dowluru SVGK %D 2021 %J Journal of Oncology Research and Therapy (ISSN: 2574-710X) %K DNAmethylation Gastriccancer H. Moleculartherapy pylori %P 15 %R 10.29011/2574-710X.010106 %T DNA Methylation Studies and Molecular Therapy of Helicobacter pylori Strain for the Treatment of Gastric Cancer %U https://www.gavinpublishers.com/article/view/dna-methylation-studies-and-molecular-therapy-of-helicobacter-pylori-strain-for-the-treatment-of-gastric-cancer %V 5 %X DNA methylation is a cellular process in which DNA methyltransferase regulates in addition of a methyl group to DNA,which is an epigenetic and heritable alteration that leads to cancer. About 62 genes are reported as methylated as per SCDb database and based on analysis, CDH1 (Cadherin 1) gene is showing a good characteristic relationship with gastric cancer that is caused by Helicobacter pylori. The Methylation frequency above 50 is shown in genes like APC, BRCA1, DAPK1, and RARB.Tissue-specific circular RNA induction in the human fetal development is increased from 10 week to 20 week gradually due tothe genes like CDH1, PTEN, HLA-B and TIMP3. Due to CDH1 gene mutation, Beta–catenin suppresses the T-cell responses and promotes the development of tumors due to H. pylori infection. The selected molecules like Pravastatin, Clopidogrel, Magnesium Sulfate and Nicotine have shown control of mutated APC and CDH1 proteins. The Pravastatin has shown best activity mutated APC and CDH1 proteins. Magnesium Sulfate has shown least activity in control of CDH1 and APC proteins. Hence the present work confirms that Pravastatin is the best option for the molecular therapy in control of gastric cancer followed by drugs like Clopidogrel, Nicotine and Magnesium Sulfate.

@article{kaladhar2021methylation, abstract = {DNA methylation is a cellular process in which DNA methyltransferase regulates in addition of a methyl group to DNA,which is an epigenetic and heritable alteration that leads to cancer. About 62 genes are reported as methylated as per SCDb database and based on analysis, CDH1 (Cadherin 1) gene is showing a good characteristic relationship with gastric cancer that is caused by Helicobacter pylori. The Methylation frequency above 50 is shown in genes like APC, BRCA1, DAPK1, and RARB.Tissue-specific circular RNA induction in the human fetal development is increased from 10 week to 20 week gradually due tothe genes like CDH1, PTEN, HLA-B and TIMP3. Due to CDH1 gene mutation, Beta–catenin suppresses the T-cell responses and promotes the development of tumors due to H. pylori infection. The selected molecules like Pravastatin, Clopidogrel, Magnesium Sulfate and Nicotine have shown control of mutated APC and CDH1 proteins. The Pravastatin has shown best activity mutated APC and CDH1 proteins. Magnesium Sulfate has shown least activity in control of CDH1 and APC proteins. Hence the present work confirms that Pravastatin is the best option for the molecular therapy in control of gastric cancer followed by drugs like Clopidogrel, Nicotine and Magnesium Sulfate.}, added-at = {2021-11-24T11:53:41.000+0100}, author = {Kaladhar, Dowluru SVGK}, biburl = {https://www.bibsonomy.org/bibtex/29ef970a43dccb27dfabe63d123051d54/alyssacarter}, doi = {10.29011/2574-710X.010106}, interhash = {b5afbaaedb97f19bcbb33f728d428a7a}, intrahash = {9ef970a43dccb27dfabe63d123051d54}, issn = {2574-710X}, journal = {Journal of Oncology Research and Therapy (ISSN: 2574-710X)}, keywords = {DNAmethylation Gastriccancer H. Moleculartherapy pylori}, language = {ENGLISH}, month = {August}, pages = 15, timestamp = {2021-11-24T11:53:41.000+0100}, title = {DNA Methylation Studies and Molecular Therapy of Helicobacter pylori Strain for the Treatment of Gastric Cancer}, url = {https://www.gavinpublishers.com/article/view/dna-methylation-studies-and-molecular-therapy-of-helicobacter-pylori-strain-for-the-treatment-of-gastric-cancer}, volume = 5, year = 2021 }