%0 Journal Article %1 Dick.2012 %A Dick, Michelle G. %A Versmold, Beatrix %A Engel, Christoph %A Meindl, Alfons %A Arnold, Norbert %A Varon-Mateeva, Raymonda %A Sutter, Christian %A Niederacher, Dieter %A Deissler, Helmut %A Preisler-Adams, Sabine %A Kast, Karin %A Schäfer, Dieter %A Gadzicki, Dorothea %A Heinritz, Wolfram %A Wappenschmidt, Barbara %A Schmutzler, Rita K. %D 2012 %J International journal of cancer. Journal international du cancer %K Adolescent Alleles BRCA2_Protein/genetics Breast_Neoplasms/genetics Female Genetic_Predisposition_to_Disease Genotype Humans Mutation Ovarian_Neoplasms/genetics Polymorphism,_Single_Nucleotide Proportional_Hazards_Models Receptors,_TNF-Related_Apoptosis-Inducing_Ligand/genetics Ubiquitin-Protein_Ligases/genetics %N 6 %P 1314–1318 %T Association of death receptor 4 variant (683A C) with ovarian cancer risk in BRCA1 mutation carriers %V 130 %X Dysregulation of apoptosis plays an important role in carcinogenesis. Therefore, apoptosis-associated genes like the death receptor 4 (DR4, TRAIL-R1) are interesting candidates for modifying the penetrance of breast and ovarian cancer in carriers of BRCA1 and BRCA2 mutations. The DR-4 haplotype 626C-683C 626C > G, Thr209Arg (rs4871857) and 683A > C, Glu228Ala (rs17088993) has recently been linked to an increased risk of breast cancer. To evaluate whether DR4 626C > G or DR4 683A > C modifies the risk of breast or ovarian cancer in carriers of BRCA1 and BRCA2 mutations, we undertook a national multicenter study including data of 840 carriers of breast cancer gene (BRCA) mutations. DNA samples were collected from 12 German research centers between 1996 and 2005 and were genotyped by the Taqman allelic discrimination assay. The association between genotypes and incidence of breast or ovarian cancer data was evaluated using a Cox proportional hazards regression model. We found evidence for a significant association of DR4 683A > C with a higher risk for ovarian cancer in carriers of BRCA1 mutations n = 557, hazard ratio 1.78 (1.24-2.55), p = 0.009. Our results thus indicate that the DR4 683A > C variant modifies the risk of ovarian cancer in carriers of BRCA1 mutations.

@article{Dick.2012, abstract = {Dysregulation of apoptosis plays an important role in carcinogenesis. Therefore, apoptosis-associated genes like the death receptor 4 (DR4, TRAIL-R1) are interesting candidates for modifying the penetrance of breast and ovarian cancer in carriers of BRCA1 and BRCA2 mutations. The DR-4 haplotype 626C-683C [626C > G, Thr209Arg (rs4871857) and 683A > C, Glu228Ala (rs17088993)] has recently been linked to an increased risk of breast cancer. To evaluate whether DR4 626C > G or DR4 683A > C modifies the risk of breast or ovarian cancer in carriers of BRCA1 and BRCA2 mutations, we undertook a national multicenter study including data of 840 carriers of breast cancer gene (BRCA) mutations. DNA samples were collected from 12 German research centers between 1996 and 2005 and were genotyped by the Taqman allelic discrimination assay. The association between genotypes and incidence of breast or ovarian cancer data was evaluated using a Cox proportional hazards regression model. We found evidence for a significant association of DR4 683A > C with a higher risk for ovarian cancer in carriers of BRCA1 mutations [n = 557, hazard ratio 1.78 (1.24-2.55), p = 0.009]. Our results thus indicate that the DR4 683A > C variant modifies the risk of ovarian cancer in carriers of BRCA1 mutations.}, added-at = {2014-10-13T18:24:43.000+0200}, author = {Dick, Michelle G. and Versmold, Beatrix and Engel, Christoph and Meindl, Alfons and Arnold, Norbert and Varon-Mateeva, Raymonda and Sutter, Christian and Niederacher, Dieter and Deissler, Helmut and Preisler-Adams, Sabine and Kast, Karin and Schäfer, Dieter and Gadzicki, Dorothea and Heinritz, Wolfram and Wappenschmidt, Barbara and Schmutzler, Rita K.}, biburl = {https://www.bibsonomy.org/bibtex/2a98f6f89d729ce9ec52b53cacba71923/drtester}, interhash = {6f393c58cd105d50c6ca49c462ec1535}, intrahash = {a98f6f89d729ce9ec52b53cacba71923}, journal = {International journal of cancer. Journal international du cancer}, keywords = {Adolescent Alleles BRCA2_Protein/genetics Breast_Neoplasms/genetics Female Genetic_Predisposition_to_Disease Genotype Humans Mutation Ovarian_Neoplasms/genetics Polymorphism,_Single_Nucleotide Proportional_Hazards_Models Receptors,_TNF-Related_Apoptosis-Inducing_Ligand/genetics Ubiquitin-Protein_Ligases/genetics}, number = 6, pages = {1314–1318}, timestamp = {2014-10-13T18:24:43.000+0200}, title = {Association of death receptor 4 variant (683A C) with ovarian cancer risk in BRCA1 mutation carriers}, volume = 130, year = 2012 }