Nuclear factor kappa B (NF-κB) is an important factor linking inflammation and tumorigenesis. In this study we experimentally demonstrated through a high-throughput luciferase reporter screen that NF-κB signaling can be directly targeted by nearly 29 microRNAs (miRNAs). Many of these miRNAs can directly target NF-κB signaling nodes by binding to their 3' untranslated region (UTR). miR-195, a member of the miR-15 family, is frequently down-regulated in gastrointestinal cancers, especially in hepatocellular carcinoma (HCC). The expression level of miR-195 is inversely correlated with HCC tumor size. We further show that miR-195 suppresses cancer cell proliferation and migration in vitro and reduces tumorigenicity and metastasis in vivo. Additionally, miR-195 may exert its tumor suppressive function by decreasing the expression of multiple NF-κB downstream effectors by way of the direct targeting of IKKα and TAB3.
CONCLUSION:
Multiple miRNAs are involved in the NF-κB signaling pathway and miR-195 plays important inhibitory roles in cancer progression and may be a potential therapeutic target.
Description
This article provides useful information about the function of miR-195. This microRNA was one the article by Shi et al. found significant in hepatocellular carcinoma. This article provided information on what it actually did.
%0 Journal Article
%1 ding2013genomewide
%A Ding, Jie
%A Huang, Shengling
%A Wang, Ying
%A Tian, Qi
%A Zha, Ruopeng
%A Shi, Haibing
%A Wang, Qifeng
%A Ge, Chao
%A Chen, Taoyang
%A Zhao, Yingjun
%A Liang, Linhui
%A Li, Jinjun
%A He, Xianghuo
%D 2013
%J Hepatology
%K 3 background cancer epigenetics mirnas
%N 2
%P 654-666
%R 10.1002/hep.26378
%T Genome-wide screening reveals that miR-195 targets the TNF-α/NF-кB pathway by down-regulating IкB kinase alpha and TAB3 in hepatocellular carcinoma
%U http://onlinelibrary.wiley.com/doi/10.1002/hep.26378/full
%V 58
%X Nuclear factor kappa B (NF-κB) is an important factor linking inflammation and tumorigenesis. In this study we experimentally demonstrated through a high-throughput luciferase reporter screen that NF-κB signaling can be directly targeted by nearly 29 microRNAs (miRNAs). Many of these miRNAs can directly target NF-κB signaling nodes by binding to their 3' untranslated region (UTR). miR-195, a member of the miR-15 family, is frequently down-regulated in gastrointestinal cancers, especially in hepatocellular carcinoma (HCC). The expression level of miR-195 is inversely correlated with HCC tumor size. We further show that miR-195 suppresses cancer cell proliferation and migration in vitro and reduces tumorigenicity and metastasis in vivo. Additionally, miR-195 may exert its tumor suppressive function by decreasing the expression of multiple NF-κB downstream effectors by way of the direct targeting of IKKα and TAB3.
CONCLUSION:
Multiple miRNAs are involved in the NF-κB signaling pathway and miR-195 plays important inhibitory roles in cancer progression and may be a potential therapeutic target.
@article{ding2013genomewide,
abstract = {Nuclear factor kappa B (NF-κB) is an important factor linking inflammation and tumorigenesis. In this study we experimentally demonstrated through a high-throughput luciferase reporter screen that NF-κB signaling can be directly targeted by nearly 29 microRNAs (miRNAs). Many of these miRNAs can directly target NF-κB signaling nodes by binding to their 3' untranslated region (UTR). miR-195, a member of the miR-15 family, is frequently down-regulated in gastrointestinal cancers, especially in hepatocellular carcinoma (HCC). The expression level of miR-195 is inversely correlated with HCC tumor size. We further show that miR-195 suppresses cancer cell proliferation and migration in vitro and reduces tumorigenicity and metastasis in vivo. Additionally, miR-195 may exert its tumor suppressive function by decreasing the expression of multiple NF-κB downstream effectors by way of the direct targeting of IKKα and TAB3.
CONCLUSION:
Multiple miRNAs are involved in the NF-κB signaling pathway and miR-195 plays important inhibitory roles in cancer progression and may be a potential therapeutic target.},
added-at = {2017-10-04T03:51:43.000+0200},
author = {Ding, Jie and Huang, Shengling and Wang, Ying and Tian, Qi and Zha, Ruopeng and Shi, Haibing and Wang, Qifeng and Ge, Chao and Chen, Taoyang and Zhao, Yingjun and Liang, Linhui and Li, Jinjun and He, Xianghuo},
biburl = {https://www.bibsonomy.org/bibtex/2b10635205adbb32a365869bf5035ddf3/artheibault},
description = {This article provides useful information about the function of miR-195. This microRNA was one the article by Shi et al. found significant in hepatocellular carcinoma. This article provided information on what it actually did.},
doi = {10.1002/hep.26378},
interhash = {f959428893e7a5e7df7b5ba70b7a7a4f},
intrahash = {b10635205adbb32a365869bf5035ddf3},
journal = {Hepatology},
keywords = {3 background cancer epigenetics mirnas},
number = 2,
pages = {654-666},
timestamp = {2017-10-25T22:18:31.000+0200},
title = {Genome-wide screening reveals that miR-195 targets the TNF-α/NF-кB pathway by down-regulating IкB kinase alpha and TAB3 in hepatocellular carcinoma},
url = {http://onlinelibrary.wiley.com/doi/10.1002/hep.26378/full},
volume = 58,
year = 2013
}