The mechanisms underlying the ST segment shifts associated with subendocardial
ischemia remain unclear. The aim of this paper is to shed further
light on the subject through numerical simulations of these shifts.
A realistic three-dimensional model of the ventricles, including
fiber rotation and anisotropy, is embedded in a nonhomogeneous torso
model. A simplification of the bidomain model is used to calculate
only the ST segment shift, assuming known values of the transmembrane
potential during the plateau and rest phases. A similar simulation
is performed in two dimensions. The simulation results suggest that
subendocardial ischemia can be located by ST segment shift on the
epicardial and torso surfaces. It is shown that ST elevation is associated
with the transmural ischemic boundary, while ST depression is associated
with the lateral ischemic boundaries.
%0 Journal Article
%1 MacL_2005_799
%A MacLachlan, Mary C
%A Sundnes, Joakim
%A Lines, Glenn Terje
%D 2005
%J IEEE Trans. Biomed. Eng.
%K 15887529 Body Cardiovascular, Comparative Computer Conduction Electrocardiography, Endocardium, Heart Humans, Ischemia, Mapping, Models, Myocardial Neurological, Potential Simulation, Study, Surface Synaptic System, Transmission, Ventricles,
%N 5
%P 799--807
%T Simulation of ST segment changes during subendocardial ischemia using
a realistic 3-D cardiac geometry.
%V 52
%X The mechanisms underlying the ST segment shifts associated with subendocardial
ischemia remain unclear. The aim of this paper is to shed further
light on the subject through numerical simulations of these shifts.
A realistic three-dimensional model of the ventricles, including
fiber rotation and anisotropy, is embedded in a nonhomogeneous torso
model. A simplification of the bidomain model is used to calculate
only the ST segment shift, assuming known values of the transmembrane
potential during the plateau and rest phases. A similar simulation
is performed in two dimensions. The simulation results suggest that
subendocardial ischemia can be located by ST segment shift on the
epicardial and torso surfaces. It is shown that ST elevation is associated
with the transmural ischemic boundary, while ST depression is associated
with the lateral ischemic boundaries.
@article{MacL_2005_799,
abstract = {The mechanisms underlying the ST segment shifts associated with subendocardial
ischemia remain unclear. The aim of this paper is to shed further
light on the subject through numerical simulations of these shifts.
A realistic three-dimensional model of the ventricles, including
fiber rotation and anisotropy, is embedded in a nonhomogeneous torso
model. A simplification of the bidomain model is used to calculate
only the ST segment shift, assuming known values of the transmembrane
potential during the plateau and rest phases. A similar simulation
is performed in two dimensions. The simulation results suggest that
subendocardial ischemia can be located by ST segment shift on the
epicardial and torso surfaces. It is shown that ST elevation is associated
with the transmural ischemic boundary, while ST depression is associated
with the lateral ischemic boundaries.},
added-at = {2009-06-03T11:20:58.000+0200},
author = {MacLachlan, Mary C and Sundnes, Joakim and Lines, Glenn Terje},
biburl = {https://www.bibsonomy.org/bibtex/2b3638e609587cd3bb541afd337dbd492/hake},
description = {The whole bibliography file I use.},
interhash = {c1a0c75e79b6084322b522056f6e3885},
intrahash = {b3638e609587cd3bb541afd337dbd492},
journal = {IEEE Trans. Biomed. Eng.},
keywords = {15887529 Body Cardiovascular, Comparative Computer Conduction Electrocardiography, Endocardium, Heart Humans, Ischemia, Mapping, Models, Myocardial Neurological, Potential Simulation, Study, Surface Synaptic System, Transmission, Ventricles,},
month = May,
number = 5,
pages = {799--807},
pmid = {15887529},
timestamp = {2009-06-03T11:21:21.000+0200},
title = {Simulation of ST segment changes during subendocardial ischemia using
a realistic 3-D cardiac geometry.},
volume = 52,
year = 2005
}