Complex Channel Model to explain the Unique Features of Action Potential Initiation in Cortical Neurons
M. Mastuo, и K. Aihara. Abstract Book of the XXIII IUPAP International Conference on Statistical Physics, Genova, Italy, (9-13 July 2007)
Аннотация
In this poster, we give a hypothetical model to explain the
'unique features' seen in the action potential
initiation of cortical neuron.
The unique features of action potential
--rapid initiation and variable onset potential-- were recently pointed out by B. Naundorf Ľit et al.,
and they insisted that
those features are outside the range of behaviours described by the classical Hodgkin-Huxley formalism.
On the other hand, D. A. McCormik Ľit et al. did not agree to them,
and insisted that those are due to just complexity of neuron,
that is, it is consist of various parts, i.e. dendrite, soma, axon initial segment (AIS) and axon.
However, here, we want to say that the features are due to the
sodium channel complexity.
The main part of the channel $Ľalpha$ subunit interacts with other subunit $Ľbeta_x$ which is not considered in Hodgkin-Huxley formalism.
Including the effect of $Ľbeta$ subunit to H-H type model,
we show that the two unique features are reproduced, and
the model is consistent to the other experimental observations
for $Ľbeta$ subunit.
We conclude that one sodium channel itself has high complexity to
regulate neural activity.
%0 Book Section
%1 statphys23_0953
%A Mastuo, M.Y.
%A Aihara, K.
%B Abstract Book of the XXIII IUPAP International Conference on Statistical Physics
%C Genova, Italy
%D 2007
%E Pietronero, Luciano
%E Loreto, Vittorio
%E Zapperi, Stefano
%K action channel dynamical hodgkin-huxley neuron potential statphys23 system topic-10
%T Complex Channel Model to explain the Unique Features of Action Potential Initiation in Cortical Neurons
%U http://st23.statphys23.org/webservices/abstract/preview_pop.php?ID_PAPER=953
%X In this poster, we give a hypothetical model to explain the
'unique features' seen in the action potential
initiation of cortical neuron.
The unique features of action potential
--rapid initiation and variable onset potential-- were recently pointed out by B. Naundorf Ľit et al.,
and they insisted that
those features are outside the range of behaviours described by the classical Hodgkin-Huxley formalism.
On the other hand, D. A. McCormik Ľit et al. did not agree to them,
and insisted that those are due to just complexity of neuron,
that is, it is consist of various parts, i.e. dendrite, soma, axon initial segment (AIS) and axon.
However, here, we want to say that the features are due to the
sodium channel complexity.
The main part of the channel $Ľalpha$ subunit interacts with other subunit $Ľbeta_x$ which is not considered in Hodgkin-Huxley formalism.
Including the effect of $Ľbeta$ subunit to H-H type model,
we show that the two unique features are reproduced, and
the model is consistent to the other experimental observations
for $Ľbeta$ subunit.
We conclude that one sodium channel itself has high complexity to
regulate neural activity.
@incollection{statphys23_0953,
abstract = {In this poster, we give a hypothetical model to explain the
'unique features' seen in the action potential
initiation of cortical neuron.
The unique features of action potential
--rapid initiation and variable onset potential-- were recently pointed out by B. Naundorf {Ľit et al.},
and they insisted that
those features are outside the range of behaviours described by the classical Hodgkin-Huxley formalism.
On the other hand, D. A. McCormik {Ľit et al.} did not agree to them,
and insisted that those are due to just complexity of neuron,
that is, it is consist of various parts, i.e. dendrite, soma, axon initial segment (AIS) and axon.
However, here, we want to say that the features are due to the
sodium channel complexity.
The main part of the channel $Ľalpha$ subunit interacts with other subunit $Ľbeta_x$ which is not considered in Hodgkin-Huxley formalism.
Including the effect of $Ľbeta$ subunit to H-H type model,
we show that the two unique features are reproduced, and
the model is consistent to the other experimental observations
for $Ľbeta$ subunit.
We conclude that one sodium channel itself has high complexity to
regulate neural activity.},
added-at = {2007-06-20T10:16:09.000+0200},
address = {Genova, Italy},
author = {Mastuo, M.Y. and Aihara, K.},
biburl = {https://www.bibsonomy.org/bibtex/2bb5bb6e0fe6866f5aa20a40cba923c66/statphys23},
booktitle = {Abstract Book of the XXIII IUPAP International Conference on Statistical Physics},
editor = {Pietronero, Luciano and Loreto, Vittorio and Zapperi, Stefano},
interhash = {7bc27ce997c295a26c92ab2327addfc1},
intrahash = {bb5bb6e0fe6866f5aa20a40cba923c66},
keywords = {action channel dynamical hodgkin-huxley neuron potential statphys23 system topic-10},
month = {9-13 July},
timestamp = {2007-06-20T10:16:35.000+0200},
title = {Complex Channel Model to explain the Unique Features of Action Potential Initiation in Cortical Neurons},
url = {http://st23.statphys23.org/webservices/abstract/preview_pop.php?ID_PAPER=953},
year = 2007
}