%0 Journal Article %1 huygen_inhomogeneity_index_1993 %A Huygen, PEM %A Gültuna, I. %A Ince, C %A Zwart, A %A Bogaard, JM %A Feenstra, BW %A Bruining, HA %D 1993 %J Crit Care Med %K COPD becklake gas-transport index inhomogeneity intensive-care mass-spectrometer mechanical-ventilation pulmonary-disease tiffeneau ventilation volumes-regression-index washout %N 8 %P 1149--1158 %T A new ventilation inhomogeneity index from multiple breath indicator gas washout tests in mechanically ventilated patients %V 21 %X OBJECTIVES: a) To determine the validity of a new method to analyze indicator gas washout tests on mechanically ventilated patients. This method takes into account the difference between the end-expiratory gas fraction and the mean gas fraction in the lung and provides the end-expiratory lung volume and a new index of ventilation inhomogeneity called volumes regression index. b) To determine the validity of this index as a predictor of chronic obstructive pulmonary disease. c) To compare this index with the moment ratio index and Becklake index. DESIGN: Prospective study of diagnostic test. Criterium standards: Closed-circuit indicator gas dilution technique and Tiffeneau index. SETTING: Surgical intensive care unit of a university hospital. PATIENTS: A total of 38 mechanically ventilated postoperative patients, divided into two groups: the obstructive group (n = 21) and the nonobstructive group (n = 17), based on their preoperative lung function. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: a) The mean coefficient of variation of all lung volume measurements in a group of nine healthy volunteers was 5\%, and the difference between this technique and the closed-circuit helium dilution measurements was -2 +/- 5\%. In patients, the mean coefficient of variation of the lung volume measurements was 3.5\%. The volumes regression index was measured as 0.02 +/- 0.04 in a dummy lung, 0.37 +/- 0.08 in the healthy volunteers, 0.64 +/- 0.23 in the nonobstructive patients, and 1.1 +/- 0.3 in the obstructive patients. The volumes regression index provided a better correlation (r2 = .46) with preoperatively determined Tiffeneau index than the Becklake index (r2 = .11) or the moment ratio index (r2 = .18). CONCLUSION: The proposed technique provides a means for accurate measurement of the end-expiratory lung volume and the amount of ventilation inhomogeneity in mechanically ventilated intensive care unit patients.

@article{huygen_inhomogeneity_index_1993, abstract = {OBJECTIVES: a) To determine the validity of a new method to analyze indicator gas washout tests on mechanically ventilated patients. This method takes into account the difference between the end-expiratory gas fraction and the mean gas fraction in the lung and provides the end-expiratory lung volume and a new index of ventilation inhomogeneity called volumes regression index. b) To determine the validity of this index as a predictor of chronic obstructive pulmonary disease. c) To compare this index with the moment ratio index and Becklake index. DESIGN: Prospective study of diagnostic test. Criterium standards: Closed-circuit indicator gas dilution technique and Tiffeneau index. SETTING: Surgical intensive care unit of a university hospital. PATIENTS: A total of 38 mechanically ventilated postoperative patients, divided into two groups: the obstructive group (n = 21) and the nonobstructive group (n = 17), based on their preoperative lung function. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: a) The mean coefficient of variation of all lung volume measurements in a group of nine healthy volunteers was 5\%, and the difference between this technique and the closed-circuit helium dilution measurements was -2 +/- 5\%. In patients, the mean coefficient of variation of the lung volume measurements was 3.5\%. The volumes regression index was measured as 0.02 +/- 0.04 in a dummy lung, 0.37 +/- 0.08 in the healthy volunteers, 0.64 +/- 0.23 in the nonobstructive patients, and 1.1 +/- 0.3 in the obstructive patients. The volumes regression index provided a better correlation (r2 = .46) with preoperatively determined Tiffeneau index than the Becklake index (r2 = .11) or the moment ratio index (r2 = .18). CONCLUSION: The proposed technique provides a means for accurate measurement of the end-expiratory lung volume and the amount of ventilation inhomogeneity in mechanically ventilated intensive care unit patients.}, added-at = {2009-03-04T11:23:03.000+0100}, author = {Huygen, PEM and Gültuna, I. and Ince, C and Zwart, A and Bogaard, JM and Feenstra, BW and Bruining, HA}, biburl = {https://www.bibsonomy.org/bibtex/2c2228dee919278eee9a2c8ba29f9fae6/paulhuygen}, interhash = {5289aad38b0ffb08ec9123af32441b28}, intrahash = {c2228dee919278eee9a2c8ba29f9fae6}, journal = {Crit Care Med}, keywords = {COPD becklake gas-transport index inhomogeneity intensive-care mass-spectrometer mechanical-ventilation pulmonary-disease tiffeneau ventilation volumes-regression-index washout}, month = aug, number = 8, pages = {1149--1158}, timestamp = {2009-03-04T11:23:03.000+0100}, title = {A new ventilation inhomogeneity index from multiple breath indicator gas washout tests in mechanically ventilated patients}, volume = 21, year = 1993 }