Effects of calcitonin injected into various brain areas on pain threshold and Ca2+ in rats

, , and . Zhongguo yao li xue bao = Acta pharmacologica Sinica 17 (3): 218--220 (May 1996)


AIM: To study the effects of calcitonin (Cal) injected into different brain areas on pain threshold. METHODS: The analgesic effects of Cal were investigated in rats by the tail-flick test. RESULTS: Cal injected into lateral cerebral ventricle (LCV) or periaqueductal gray (PAG) increased obviously the pain threshold to 49 +/- 22\% or to 68 +/- 12\% (P \textless 0.01), respectively. When PAG was blocked with lidocaine, the analgesic effect of Cal injected into LCV was lowered 41 +/- 9\%. Cal injected into habenula (Hab) decreased the pain threshold to -30 +/- 5\% (P \textless 0.01). CONCLUSION: Cal in different rat brain areas induced different effects on pain responses: analgesia or hyperalgesia, and showed that PAG played an important role in the analgesic effect induced by Cal, and the changing of pain threshold was mediated by the Ca2+ in brain.

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