%0 Journal Article %1 lin_covariance_2014 %A Lin, Eugene C %A Opella, Stanley J %D 2014 %J J. Magn. Reson. %K Algorithms,Bacteriophage Isotopes,Nuclear Magnetic Pf1,Biomolecular,Capsid Processing,Signal-To-Noise Proteins,Computer-Assisted,Nitrogen Ratio Resonance,Reproducibility Results,Signal of %P 57--60 %R 10.1016/j.jmr.2013.11.018 %T Covariance spectroscopy in high-resolution multi-dimensional solid-state \NMR\ %V 239 %X Covariance spectroscopy (COV), a statistical method that provides increased sensitivity, can be applied to two-dimensional high-resolution solid-state NMR experiments, such as homonuclear spin-exchange spectroscopy. We the alternative States sampling scheme to the experimental time by 50\%. By combining COV with other processing methods for non-uniform sampling (NUS), many different three-dimensional experiments can be performed with substantial increases in overall sensitivity. As an example, we show a three-dimensional homonuclear spin-exchange/separated-local-field (SLF) spectrum that enables the assignment of resonances and the measurement of structural restraints from a single experiment performed in a limited amount of time.

@article{lin_covariance_2014, abstract = {Covariance spectroscopy (COV), a statistical method that provides increased sensitivity, can be applied to two-dimensional high-resolution solid-state NMR experiments, such as homonuclear spin-exchange spectroscopy. We the alternative States sampling scheme to the experimental time by 50{\%}. By combining COV with other processing methods for non-uniform sampling (NUS), many different three-dimensional experiments can be performed with substantial increases in overall sensitivity. As an example, we show a three-dimensional homonuclear spin-exchange/separated-local-field (SLF) spectrum that enables the assignment of resonances and the measurement of structural restraints from a single experiment performed in a limited amount of time.}, added-at = {2017-03-14T02:48:56.000+0100}, author = {Lin, Eugene C and Opella, Stanley J}, biburl = {https://www.bibsonomy.org/bibtex/2d1b9bc6823f9d61c2881ead35c3696e4/nmrresource}, doi = {10.1016/j.jmr.2013.11.018}, interhash = {083cc7a7d47669746b12abb7a8e2b0c5}, intrahash = {d1b9bc6823f9d61c2881ead35c3696e4}, issn = {1096-0856}, journal = {J. Magn. Reson.}, keywords = {Algorithms,Bacteriophage Isotopes,Nuclear Magnetic Pf1,Biomolecular,Capsid Processing,Signal-To-Noise Proteins,Computer-Assisted,Nitrogen Ratio Resonance,Reproducibility Results,Signal of}, month = feb, pages = {57--60}, pmid = {24380813}, timestamp = {2017-03-14T02:49:21.000+0100}, title = {{Covariance spectroscopy in high-resolution multi-dimensional solid-state {\{}NMR{\}}}}, volume = 239, year = 2014 }