Purpose:
To investigate the potential of real-time magnetic particle imaging (MPI) to guide percutaneous transluminal angioplasty (PTA) of vascular stenoses in a phantom model.
Materials and Methods:
Experiments were conducted on a custom-built MPI scanner. Vascular stenosis phantoms consisted of polyvinyl chloride tubes (inner diameter 8 mm) prepared with a centrally aligned cable tie to form ~ 50% stenoses. MPI angiography for visualization of stenoses was performed using the superparamagnetic iron oxide nanoparticle-based contrast agent Ferucarbotran (10 mmol (Fe)/l). Balloon catheters and guidewires for PTA were visualized using custom-made lacquer markers based on Ferucarbotran. Stenosis dilation (n = 3) was performed by manually inflating the PTA balloon with diluted Ferucarbotran. An online reconstruction framework was implemented for real-time imaging with very short latency time.
Results:
Visualization of stenosis phantoms and guidance of interventional instruments in real-time (4 frames/s, ~ 100 ms latency time) was possible using an online reconstruction algorithm. Labeling of guidewires and balloon catheters allowed for precise visualization of instrument positions.
Conclusion:
Real-time MPI-guided PTA in a phantom model is feasible.
%0 Journal Article
%1 herz2018magnetic
%A Herz, Stefan
%A Vogel, Patrick
%A Dietrich, Philipp
%A Kampf, Thomas
%A Rückert, Martin A.
%A Kickuth, Ralph
%A Behr, Volker C.
%A Bley, Thorsten A.
%D 2018
%J Cardiovasc. Intervent. Radiol.
%K mpi
%N 7
%P 1100-1105
%R 10.1007/s00270-018-1955-7
%T Magnetic Particle Imaging Guided Real-Time Percutaneous Transluminal Angioplasty in a Phantom Model
%V 41
%X Purpose:
To investigate the potential of real-time magnetic particle imaging (MPI) to guide percutaneous transluminal angioplasty (PTA) of vascular stenoses in a phantom model.
Materials and Methods:
Experiments were conducted on a custom-built MPI scanner. Vascular stenosis phantoms consisted of polyvinyl chloride tubes (inner diameter 8 mm) prepared with a centrally aligned cable tie to form ~ 50% stenoses. MPI angiography for visualization of stenoses was performed using the superparamagnetic iron oxide nanoparticle-based contrast agent Ferucarbotran (10 mmol (Fe)/l). Balloon catheters and guidewires for PTA were visualized using custom-made lacquer markers based on Ferucarbotran. Stenosis dilation (n = 3) was performed by manually inflating the PTA balloon with diluted Ferucarbotran. An online reconstruction framework was implemented for real-time imaging with very short latency time.
Results:
Visualization of stenosis phantoms and guidance of interventional instruments in real-time (4 frames/s, ~ 100 ms latency time) was possible using an online reconstruction algorithm. Labeling of guidewires and balloon catheters allowed for precise visualization of instrument positions.
Conclusion:
Real-time MPI-guided PTA in a phantom model is feasible.
@article{herz2018magnetic,
abstract = {Purpose:
To investigate the potential of real-time magnetic particle imaging (MPI) to guide percutaneous transluminal angioplasty (PTA) of vascular stenoses in a phantom model.
Materials and Methods:
Experiments were conducted on a custom-built MPI scanner. Vascular stenosis phantoms consisted of polyvinyl chloride tubes (inner diameter 8 mm) prepared with a centrally aligned cable tie to form ~ 50% stenoses. MPI angiography for visualization of stenoses was performed using the superparamagnetic iron oxide nanoparticle-based contrast agent Ferucarbotran (10 mmol (Fe)/l). Balloon catheters and guidewires for PTA were visualized using custom-made lacquer markers based on Ferucarbotran. Stenosis dilation (n = 3) was performed by manually inflating the PTA balloon with diluted Ferucarbotran. An online reconstruction framework was implemented for real-time imaging with very short latency time.
Results:
Visualization of stenosis phantoms and guidance of interventional instruments in real-time (4 frames/s, ~ 100 ms latency time) was possible using an online reconstruction algorithm. Labeling of guidewires and balloon catheters allowed for precise visualization of instrument positions.
Conclusion:
Real-time MPI-guided PTA in a phantom model is feasible.},
added-at = {2018-04-19T17:10:23.000+0200},
author = {Herz, Stefan and Vogel, Patrick and Dietrich, Philipp and Kampf, Thomas and R{\"u}ckert, Martin A. and Kickuth, Ralph and Behr, Volker C. and Bley, Thorsten A.},
biburl = {https://www.bibsonomy.org/bibtex/2e41a8528d6d0e98a505fb54f6a064710/ep5mpi},
doi = {10.1007/s00270-018-1955-7},
interhash = {f76c2a02b4bf3648bb39a247ae2fc330},
intrahash = {e41a8528d6d0e98a505fb54f6a064710},
issn = {0174-1551},
journal = {Cardiovasc. Intervent. Radiol.},
keywords = {mpi},
month = {7},
number = 7,
pages = {1100-1105},
timestamp = {2018-06-07T15:53:43.000+0200},
title = {Magnetic Particle Imaging Guided Real-Time Percutaneous Transluminal Angioplasty in a Phantom Model},
volume = 41,
year = 2018
}