This chapter introduces a new holistic organization transformation (i.e. Organization 2.0) caused by changes in the act of collaboration (i.e. Collaboration 2.0) due to the emergence of Web 2.0 technologies and their use by a new generation of people called Gen Y. Organization 2.0 is based on Social Capital where end-user participation, emergence of social networks and online communities, mass collaboration, and open innovation, have become new levers to put collective intelligence (e.g. crowdsourcing) at the service of the organization, to boost its performance, and to develop its creative capabilities. This chapter tries to sort out confusion that may exist between different concepts like Web 2.0, Enterprise 2.0, Collaboration 2.0, Management 2.0, KM 2.0, Organization 2.0, et cetera.