There is a steadily growing body of experimental data describing the
diffusion of acetylcholine in the neuromuscular junction and the
subsequent miniature endplate currents produced at the postsynaptic
membrane. To gain further insights into the structural features governing
synaptic transmission, we have performed calculations using a simplified
finite element model of the neuromuscular junction. The diffusing
acetylcholine molecules are modeled as a continuum, whose spatial
and temporal distribution is governed by the force-free diffusion
equation. The finite element method was adopted because of its flexibility
in modeling irregular geometries and complex boundary conditions.
The resulting simulations are shown to be in accord with experiment
and other simulations.
%0 Journal Article
%1 Smar_1998_1679
%A Smart, J. L.
%A McCammon, J. A.
%D 1998
%J Biophys. J.
%K 9746510 Acetylcholine, Acetylcholinesterase, Agents, Animals, Cholinergic, Diffusion, Endplate, Gov't, Junction, Models, Motor Neurological, Neuromuscular Neurotransmitter Nicotinic, P.H.S., Receptors, Research Support, Synapses, Synaptic Transmission, U.S.
%N 4
%P 1679--1688
%T Analysis of synaptic transmission in the neuromuscular junction using
a continuum finite element model.
%U http://www.biophysj.org/cgi/content/full/75/4/1679
%V 75
%X There is a steadily growing body of experimental data describing the
diffusion of acetylcholine in the neuromuscular junction and the
subsequent miniature endplate currents produced at the postsynaptic
membrane. To gain further insights into the structural features governing
synaptic transmission, we have performed calculations using a simplified
finite element model of the neuromuscular junction. The diffusing
acetylcholine molecules are modeled as a continuum, whose spatial
and temporal distribution is governed by the force-free diffusion
equation. The finite element method was adopted because of its flexibility
in modeling irregular geometries and complex boundary conditions.
The resulting simulations are shown to be in accord with experiment
and other simulations.
@article{Smar_1998_1679,
abstract = {There is a steadily growing body of experimental data describing the
diffusion of acetylcholine in the neuromuscular junction and the
subsequent miniature endplate currents produced at the postsynaptic
membrane. To gain further insights into the structural features governing
synaptic transmission, we have performed calculations using a simplified
finite element model of the neuromuscular junction. The diffusing
acetylcholine molecules are modeled as a continuum, whose spatial
and temporal distribution is governed by the force-free diffusion
equation. The finite element method was adopted because of its flexibility
in modeling irregular geometries and complex boundary conditions.
The resulting simulations are shown to be in accord with experiment
and other simulations.},
added-at = {2009-06-03T11:20:58.000+0200},
author = {Smart, J. L. and McCammon, J. A.},
biburl = {https://www.bibsonomy.org/bibtex/2e70bc56409fe81a027cfaf075ea00241/hake},
description = {The whole bibliography file I use.},
file = {Smar_1998_1679.pdf:Smar_1998_1679.pdf:PDF},
interhash = {11604b1c421f1617c06489bd0c0c332f},
intrahash = {e70bc56409fe81a027cfaf075ea00241},
journal = {Biophys. J.},
keywords = {9746510 Acetylcholine, Acetylcholinesterase, Agents, Animals, Cholinergic, Diffusion, Endplate, Gov't, Junction, Models, Motor Neurological, Neuromuscular Neurotransmitter Nicotinic, P.H.S., Receptors, Research Support, Synapses, Synaptic Transmission, U.S.},
month = Oct,
number = 4,
pages = {1679--1688},
pmid = {9746510},
timestamp = {2009-06-03T11:21:31.000+0200},
title = {Analysis of synaptic transmission in the neuromuscular junction using
a continuum finite element model.},
url = {http://www.biophysj.org/cgi/content/full/75/4/1679},
volume = 75,
year = 1998
}