%0 Journal Article %1 preskorn2007comparison %A Preskorn, Sheldon H. %A Greenblatt, David J. %A Flockhart, David A. %A Luo, Yan %A Perloff, Elke S. %A Harmatz, Jerold S. %A Baker, Bryan %A Klick-Davis, Alisa %A Desta, Zereusenay %A Burt, Tal %D 2007 %J Journal of Clinical Psychopharmacology %K depression genetics gratis medicine pharma psychiatry research %N 1 %P 28-34 %R 10.1097/00004714-200702000-00005 %T Comparison of duloxetine, escitalopram, and sertraline effects on cytochrome P450 2D6 function in healthy volunteers %U https://www.researchgate.net/publication/6576977_Comparison_of_Duloxetine_Escitalopram_and_Sertraline_Effects_on_Cytochrome_P450_2D6_Function_in_Healthy_Volunteers %V 27 %X This study is the first to directly compare the relative effects of duloxetine, escitalopram, and sertraline on the functional activity of the drug-metabolizing cytochrome P450 2D6 enzyme as assessed by changes in the pharmacokinetics of the cytochrome P450 2D6 model substrate drug, metoprolol. Single-dose pharmacokinetics of metoprolol were measured before and after 17 days of treatment with escitalopram 20 mg/d, duloxetine 60 mg/d, or sertraline 100 mg/d in young healthy male and female participants. The outcome measures were changes in metoprolol peak plasma levels, area under the plasma concentration-time curve, and clearance. The results were tested using paired t tests and independent t tests. The addition of each drug produced statistically significant changes in metoprolol pharmacokinetics. The rank order for the change in metoprolol area under the plasma concentration-time curve was duloxetine (180%) > escitalopram (89%) > sertraline (48% and 67%). Compared with sertraline, duloxetine produced statistically significantly larger changes in metoprolol pharmacokinetic parameters. The changes produced by escitalopram and sertraline were not statistically different.

@article{preskorn2007comparison, abstract = {This study is the first to directly compare the relative effects of duloxetine, escitalopram, and sertraline on the functional activity of the drug-metabolizing cytochrome P450 2D6 enzyme as assessed by changes in the pharmacokinetics of the cytochrome P450 2D6 model substrate drug, metoprolol. Single-dose pharmacokinetics of metoprolol were measured before and after 17 days of treatment with escitalopram 20 mg/d, duloxetine 60 mg/d, or sertraline 100 mg/d in young healthy male and female participants. The outcome measures were changes in metoprolol peak plasma levels, area under the plasma concentration-time curve, and clearance. The results were tested using paired t tests and independent t tests. The addition of each drug produced statistically significant changes in metoprolol pharmacokinetics. The rank order for the change in metoprolol area under the plasma concentration-time curve was duloxetine (180%) > escitalopram (89%) > sertraline (48% and 67%). Compared with sertraline, duloxetine produced statistically significantly larger changes in metoprolol pharmacokinetic parameters. The changes produced by escitalopram and sertraline were not statistically different.}, added-at = {2017-02-03T19:05:37.000+0100}, author = {Preskorn, Sheldon H. and Greenblatt, David J. and Flockhart, David A. and Luo, Yan and Perloff, Elke S. and Harmatz, Jerold S. and Baker, Bryan and Klick-Davis, Alisa and Desta, Zereusenay and Burt, Tal}, biburl = {https://www.bibsonomy.org/bibtex/2e7a7069fcbf1f1e75163ca73e536044b/shelley.adams}, doi = {10.1097/00004714-200702000-00005}, interhash = {0c819be7c52883b2cdfec0b932e2eb24}, intrahash = {e7a7069fcbf1f1e75163ca73e536044b}, journal = {Journal of Clinical Psychopharmacology}, keywords = {depression genetics gratis medicine pharma psychiatry research}, month = feb, number = 1, pages = {28-34}, pmid = {17224709}, timestamp = {2017-02-03T19:05:37.000+0100}, title = {Comparison of duloxetine, escitalopram, and sertraline effects on cytochrome P450 2D6 function in healthy volunteers}, url = {https://www.researchgate.net/publication/6576977_Comparison_of_Duloxetine_Escitalopram_and_Sertraline_Effects_on_Cytochrome_P450_2D6_Function_in_Healthy_Volunteers}, volume = 27, year = 2007 }