CQ cytotoxicity is related to lysosomal impairment that leads to autophagy-associated cell death, nuclei abnormalities, lipofuscinogenesis, and senescence. Also, our findings indicate that a therapeutic approach based on lysosomal chemo-sensitization triggered by CQ parallel to mitochondrial OA-toxicity may represent a promisor strategy to overcome in vivo tumor progression relied on apoptosis lessening.
%0 Journal Article
%1 tsubone2020vitro
%A Tsubone, Tayana Mazin
%A de Sousa Rocha, Cleidiane
%A Tonolli, Paulo Newton
%A II-Sei, Watanabe
%A Stolf, Beatriz Simonsen
%A Baptista, Maurício S.
%A Martins, Waleska Kerllen
%D 2020
%J Advances in Biochemistry and Biotechnology
%K Aging Autophagy Chloroquine Cytotoxicity Long-term response
%N 1
%P 15
%T In vitro Autophagy Modulation with Chloroquine: Some Lessons to Learn
%U https://www.gavinpublishers.com/article/view/in-vitro-autophagy-modulation-with-chloroquine-some-lessons-to-learn
%V 5
%X CQ cytotoxicity is related to lysosomal impairment that leads to autophagy-associated cell death, nuclei abnormalities, lipofuscinogenesis, and senescence. Also, our findings indicate that a therapeutic approach based on lysosomal chemo-sensitization triggered by CQ parallel to mitochondrial OA-toxicity may represent a promisor strategy to overcome in vivo tumor progression relied on apoptosis lessening.
@article{tsubone2020vitro,
abstract = {CQ cytotoxicity is related to lysosomal impairment that leads to autophagy-associated cell death, nuclei abnormalities, lipofuscinogenesis, and senescence. Also, our findings indicate that a therapeutic approach based on lysosomal chemo-sensitization triggered by CQ parallel to mitochondrial OA-toxicity may represent a promisor strategy to overcome in vivo tumor progression relied on apoptosis lessening.},
added-at = {2020-02-26T06:19:25.000+0100},
author = {Tsubone, Tayana Mazin and de Sousa Rocha, Cleidiane and Tonolli, Paulo Newton and II-Sei, Watanabe and Stolf, Beatriz Simonsen and Baptista, Maurício S. and Martins, Waleska Kerllen},
biburl = {https://www.bibsonomy.org/bibtex/2ecf29f7fab399bd992fd38ac70a00d40/alyssacarter},
interhash = {167787dd6a855bdd3d1576556801e73e},
intrahash = {ecf29f7fab399bd992fd38ac70a00d40},
issn = {2574-7258},
journal = {Advances in Biochemistry and Biotechnology},
keywords = {Aging Autophagy Chloroquine Cytotoxicity Long-term response},
language = {English},
month = {February},
number = 1,
pages = 15,
timestamp = {2021-10-09T12:44:53.000+0200},
title = {In vitro Autophagy Modulation with Chloroquine: Some Lessons to Learn},
url = {https://www.gavinpublishers.com/article/view/in-vitro-autophagy-modulation-with-chloroquine-some-lessons-to-learn},
volume = 5,
year = 2020
}