A community-based outbreak of infection with penicillin-resistant Neisseria gonorrhoeae not producing penicillinase (chromosomally mediated resistance)
From February through November of 1983, 199 cases of penicillin-resistant Neisseria gonorrhoeae infection were identified in a localized epidemic in Durham, North Carolina. The isolates did not produce beta-lactamase but were unusually resistant to penicillin (minimum inhibitory concentration, 2.0 to 4.0 micrograms per milliliter), and 15 of 16 patients treated with 4.8 million units of penicillin G procaine plus 1.0 g of probenecid did not respond to therapy. Recognition of the outbreak was impeded by a lack of routine surveillance for resistance other than that mediated by beta-lactamase. All epidemic isolates had a single serotype, auxotype, and antibiotic-susceptibility profile. The outbreak was halted by changing the treatment for all patients and their contacts to spectinomycin, and by intensive epidemiologic case-finding efforts. The emergence of such resistant strains poses potential major public health problems and indicates a need for reassessment of current surveillance procedures.
%0 Journal Article
%1 faruki_community-based_1985
%A Faruki, H
%A Kohmescher, R N
%A McKinney, W P
%A Sparling, P F
%D 1985
%J The New England Journal of Medicine
%K Adult, Aged, Bacterial, Carolina, Chromosomes, Disease Epidemiologic Female, G, Gonorrhea, Humans, Male, Methods, Middle Neisseria North Outbreaks, Penicillin Penicillinase, Probenecid, Procaine, Resistance, Spectinomycin gonorrhoeae, {beta-Lactamases,}
%N 10
%P 607--611
%T A community-based outbreak of infection with penicillin-resistant Neisseria gonorrhoeae not producing penicillinase (chromosomally mediated resistance)
%U http://www.ncbi.nlm.nih.gov/pubmed/3160949
%V 313
%X From February through November of 1983, 199 cases of penicillin-resistant Neisseria gonorrhoeae infection were identified in a localized epidemic in Durham, North Carolina. The isolates did not produce beta-lactamase but were unusually resistant to penicillin (minimum inhibitory concentration, 2.0 to 4.0 micrograms per milliliter), and 15 of 16 patients treated with 4.8 million units of penicillin G procaine plus 1.0 g of probenecid did not respond to therapy. Recognition of the outbreak was impeded by a lack of routine surveillance for resistance other than that mediated by beta-lactamase. All epidemic isolates had a single serotype, auxotype, and antibiotic-susceptibility profile. The outbreak was halted by changing the treatment for all patients and their contacts to spectinomycin, and by intensive epidemiologic case-finding efforts. The emergence of such resistant strains poses potential major public health problems and indicates a need for reassessment of current surveillance procedures.
@article{faruki_community-based_1985,
abstract = {From February through November of 1983, 199 cases of penicillin-resistant Neisseria gonorrhoeae infection were identified in a localized epidemic in Durham, North Carolina. The isolates did not produce beta-lactamase but were unusually resistant to penicillin (minimum inhibitory concentration, 2.0 to 4.0 micrograms per milliliter), and 15 of 16 patients treated with 4.8 million units of penicillin G procaine plus 1.0 g of probenecid did not respond to therapy. Recognition of the outbreak was impeded by a lack of routine surveillance for resistance other than that mediated by beta-lactamase. All epidemic isolates had a single serotype, auxotype, and antibiotic-susceptibility profile. The outbreak was halted by changing the treatment for all patients and their contacts to spectinomycin, and by intensive epidemiologic case-finding efforts. The emergence of such resistant strains poses potential major public health problems and indicates a need for reassessment of current surveillance procedures.},
added-at = {2011-03-11T10:05:34.000+0100},
author = {Faruki, H and Kohmescher, R N and {McKinney}, W P and Sparling, P F},
biburl = {https://www.bibsonomy.org/bibtex/2eee5ebbbe9165c147a9bf18c4e978b12/jelias},
interhash = {9e8fd80823bc3ceab3db708c08fcaebd},
intrahash = {eee5ebbbe9165c147a9bf18c4e978b12},
issn = {0028-4793},
journal = {The New England Journal of Medicine},
keywords = {Adult, Aged, Bacterial, Carolina, Chromosomes, Disease Epidemiologic Female, G, Gonorrhea, Humans, Male, Methods, Middle Neisseria North Outbreaks, Penicillin Penicillinase, Probenecid, Procaine, Resistance, Spectinomycin gonorrhoeae, {beta-Lactamases,}},
month = sep,
note = {{PMID:} 3160949},
number = 10,
pages = {607--611},
timestamp = {2011-03-11T10:05:58.000+0100},
title = {A community-based outbreak of infection with penicillin-resistant Neisseria gonorrhoeae not producing penicillinase (chromosomally mediated resistance)},
url = {http://www.ncbi.nlm.nih.gov/pubmed/3160949},
volume = 313,
year = 1985
}