Lichens are symbiotic relationship between fungi and algae or cyanobacteria. Secondary metabolites from lichens are known as lichen substances. We investigated depsidone and depside from lichens 1-6 in the context of their action to prevent gastric ulcer on the model of HCl/ethanol in mice for the first time. Doses of 30 mg/kg of lichen substances 1-6 and positive control (lansoprazole) significantly diminished the lesion index compared with negative control (treated only with HCl/EtOH). Lobaric acid 1, atranorin 2 and psoromic acid 5 reduced the gastric lesions by 76%, 63% and 65%, while for variolaric acid 3, diffractaic acid 4 and perlatolic acid 6 their values were 32%, 14% and 45%, respectively. Our results suggest that lichens have potential as a suite of gastroprotective molecules.
%0 Journal Article
%1 RN117
%A Sepulveda, B.
%A Chamy, M.C.
%A Piovano, M.
%A Areche, C.
%D 2013
%J Journal of the Chilean Chemical Society
%K acid, chilean damage, depside, depsidone, dqcauchile extract, gastric indomethacin, lichens, mucosal neutrophil-infiltration, oxidative rats stress, ulcer, water
%N 2
%P 1750-1752
%T Lichens: Might Be Considered as a Source of Gastroprotective Molecules?
%U /brokenurl#<Go to ISI>://WOS:000331237700024
%V 58
%X Lichens are symbiotic relationship between fungi and algae or cyanobacteria. Secondary metabolites from lichens are known as lichen substances. We investigated depsidone and depside from lichens 1-6 in the context of their action to prevent gastric ulcer on the model of HCl/ethanol in mice for the first time. Doses of 30 mg/kg of lichen substances 1-6 and positive control (lansoprazole) significantly diminished the lesion index compared with negative control (treated only with HCl/EtOH). Lobaric acid 1, atranorin 2 and psoromic acid 5 reduced the gastric lesions by 76%, 63% and 65%, while for variolaric acid 3, diffractaic acid 4 and perlatolic acid 6 their values were 32%, 14% and 45%, respectively. Our results suggest that lichens have potential as a suite of gastroprotective molecules.
@article{RN117,
abstract = {Lichens are symbiotic relationship between fungi and algae or cyanobacteria. Secondary metabolites from lichens are known as lichen substances. We investigated depsidone and depside from lichens 1-6 in the context of their action to prevent gastric ulcer on the model of HCl/ethanol in mice for the first time. Doses of 30 mg/kg of lichen substances 1-6 and positive control (lansoprazole) significantly diminished the lesion index compared with negative control (treated only with HCl/EtOH). Lobaric acid 1, atranorin 2 and psoromic acid 5 reduced the gastric lesions by 76%, 63% and 65%, while for variolaric acid 3, diffractaic acid 4 and perlatolic acid 6 their values were 32%, 14% and 45%, respectively. Our results suggest that lichens have potential as a suite of gastroprotective molecules.},
added-at = {2019-12-04T03:57:35.000+0100},
author = {Sepulveda, B. and Chamy, M.C. and Piovano, M. and Areche, C.},
biburl = {https://www.bibsonomy.org/bibtex/2fc6f3f22999df4c441767f7d7b774864/dqcauchile},
interhash = {4ecef85c88029b0e7d893b985dbe50fc},
intrahash = {fc6f3f22999df4c441767f7d7b774864},
issn = {0717-9707},
journal = {Journal of the Chilean Chemical Society},
keywords = {acid, chilean damage, depside, depsidone, dqcauchile extract, gastric indomethacin, lichens, mucosal neutrophil-infiltration, oxidative rats stress, ulcer, water},
number = 2,
pages = {1750-1752},
timestamp = {2019-12-04T03:58:17.000+0100},
title = {Lichens: Might Be Considered as a Source of Gastroprotective Molecules?},
type = {Journal Article},
url = {/brokenurl#<Go to ISI>://WOS:000331237700024},
volume = 58,
year = 2013
}