Artikel,

Human disease: Edges, nodes and networks

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Nature Reviews Genetics, 11 (1): 4--5 (24.11.2009)
DOI: 10.1038/nrg2720

Zusammenfassung

Classical models of genotype-to-phenotype relationships for human Mendelian disorders generally assume that a mutation causes complete loss of a gene product. A recent paper shows that an alternative, network-based approach is better suited to explain observed phenotypes.

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