%0 Journal Article %1 Yang2015Structures %A Yang, Yun %A Darbari, Vidya C. %A Zhang, Nan %A Lu, Duo %A Glyde, Robert %A Wang, Yi-Ping %A Winkelman, Jared T. %A Gourse, Richard L. %A Murakami, Katsuhiko S. %A Buck, Martin %A Zhang, Xiaodong %D 2015 %I American Association for the Advancement of Science %J Science %K polymerase regulation rna %N 6250 %P 882--885 %R 10.1126/science.aab1478 %T Structures of the RNA polymerase-σ54 reveal new and conserved regulatory strategies %U http://dx.doi.org/10.1126/science.aab1478 %V 349 %X Transcription of all genes is carried out by RNA polymerase (RNAP). The enzyme is thus a pivotal regulation point for many cell and developmental processes. In bacteria, sigma factors play a vital role in transcription regulation, with σ54 being critical for transcription of many stress response genes. Yang et al. determined the x-ray crystal structure of RNAP bound to σ54, as well as promoter DNA. In the initial inhibited state of the RNAP-σ54 complex, the σ54 blocks the template DNA from entering the RNAP active site and the downstream DNA channel.

@article{Yang2015Structures, abstract = {Transcription of all genes is carried out by {RNA} polymerase ({RNAP}). The enzyme is thus a pivotal regulation point for many cell and developmental processes. In bacteria, sigma factors play a vital role in transcription regulation, with σ54 being critical for transcription of many stress response genes. Yang et al. determined the x-ray crystal structure of {RNAP} bound to σ54, as well as promoter {DNA}. In the initial inhibited state of the {RNAP}-σ54 complex, the σ54 blocks the template {DNA} from entering the {RNAP} active site and the downstream {DNA} channel.}, added-at = {2018-12-02T16:09:07.000+0100}, author = {Yang, Yun and Darbari, Vidya C. and Zhang, Nan and Lu, Duo and Glyde, Robert and Wang, Yi-Ping and Winkelman, Jared T. and Gourse, Richard L. and Murakami, Katsuhiko S. and Buck, Martin and Zhang, Xiaodong}, biburl = {https://www.bibsonomy.org/bibtex/246a89785d63c320a7bafbe8a6e54279f/karthikraman}, citeulike-article-id = {13709884}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.aab1478}, citeulike-linkout-1 = {http://www.sciencemag.org/content/349/6250/882.abstract}, citeulike-linkout-2 = {http://www.sciencemag.org/content/349/6250/882.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/26293966}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=26293966}, day = 21, doi = {10.1126/science.aab1478}, interhash = {351d0bda1a0014ae7e23b18bd92ec9c4}, intrahash = {46a89785d63c320a7bafbe8a6e54279f}, issn = {1095-9203}, journal = {Science}, keywords = {polymerase regulation rna}, month = aug, number = 6250, pages = {882--885}, pmid = {26293966}, posted-at = {2015-08-24 10:22:57}, priority = {2}, publisher = {American Association for the Advancement of Science}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Structures of the {RNA} polymerase-σ54 reveal new and conserved regulatory strategies}, url = {http://dx.doi.org/10.1126/science.aab1478}, volume = 349, year = 2015 }