%0 Journal Article %1 browning2015accurate %A Browning, Sharon R. %A Browning, Brian L. %D 2015 %J The American Journal of Human Genetics %K IBD demographic_inference effective_population_size %N 3 %P 404 - 418 %R http://dx.doi.org/10.1016/j.ajhg.2015.07.012 %T Accurate Non-parametric Estimation of Recent Effective Population Size from Segments of Identity by Descent %U http://www.sciencedirect.com/science/article/pii/S0002929715002888 %V 97 %X Existing methods for estimating historical effective population size from genetic data have been unable to accurately estimate effective population size during the most recent past. We present a non-parametric method for accurately estimating recent effective population size by using inferred long segments of identity by descent (IBD). We found that inferred segments of \IBD\ contain information about effective population size from around 4 generations to around 50 generations ago for \SNP\ array data and to over 200 generations ago for sequence data. In human populations that we examined, the estimates of effective size were approximately one-third of the census size. We estimate the effective population size of European-ancestry individuals in the \UK\ four generations ago to be eight million and the effective population size of Finland four generations ago to be 0.7 million. Our method is implemented in the open-source \IBDNe\ software package.

@article{browning2015accurate, abstract = {Existing methods for estimating historical effective population size from genetic data have been unable to accurately estimate effective population size during the most recent past. We present a non-parametric method for accurately estimating recent effective population size by using inferred long segments of identity by descent (IBD). We found that inferred segments of \{IBD\} contain information about effective population size from around 4 generations to around 50 generations ago for \{SNP\} array data and to over 200 generations ago for sequence data. In human populations that we examined, the estimates of effective size were approximately one-third of the census size. We estimate the effective population size of European-ancestry individuals in the \{UK\} four generations ago to be eight million and the effective population size of Finland four generations ago to be 0.7 million. Our method is implemented in the open-source \{IBDNe\} software package. }, added-at = {2015-09-21T06:13:46.000+0200}, author = {Browning, Sharon R. and Browning, Brian L.}, biburl = {https://www.bibsonomy.org/bibtex/27934b3d154b0ea562852c1feb82832b6/peter.ralph}, description = {Fits a piecewise exponential demographic history to the IBD tract lengths by using demographic history as prior to estimate proportion of genome coalescing in a given time, and iterating. Doesn't include estimated false positive or error rates?}, doi = {http://dx.doi.org/10.1016/j.ajhg.2015.07.012}, interhash = {3bf723efab30c204d452fc1aae5a9984}, intrahash = {7934b3d154b0ea562852c1feb82832b6}, issn = {0002-9297}, journal = {The American Journal of Human Genetics }, keywords = {IBD demographic_inference effective_population_size}, number = 3, pages = {404 - 418}, timestamp = {2015-09-21T06:26:38.000+0200}, title = {Accurate Non-parametric Estimation of Recent Effective Population Size from Segments of Identity by Descent }, url = {http://www.sciencedirect.com/science/article/pii/S0002929715002888}, volume = 97, year = 2015 }