%0 Journal Article %1 cozzone_detection_1975 %A Cozzone, P J %A Opella, S J %A Jardetzky, O %A Berthou, J %A Jollès, P %D 1975 %J Proc. Natl. Acad. Sci. U.S.A. %K Carbon Conformation,Temperature,Tryptophan,Tyrosine Isotopes,Egg Resonance Spectroscopy,Muramidase,Protein White,Magnetic %N 6 %P 2095--2098 %T Detection of new temperature-dependent conformational transition in lysozyme by carbon-13 nuclear magnetic resonance spectroscopy %V 72 %X A specific temperature-dependent conformational transition of hen egg-white lysozyme, occurring between 20 degree C and 30 degree C in solution, has been detected by 13-C-nuclear magnetic resonance spectroscopy. Selective changes in the chemical shifts of aromatic residues, together with differences in the chemical shifts, and nuclear Overhauser enhancement in the carbonyl, carboxyl, and alpha-carbon regions of the spectrum point to the vicinity of subsites D and E as the primary locus of the structural change.

@article{cozzone_detection_1975, abstract = {A specific temperature-dependent conformational transition of hen egg-white lysozyme, occurring between 20 degree C and 30 degree C in solution, has been detected by 13-C-nuclear magnetic resonance spectroscopy. Selective changes in the chemical shifts of aromatic residues, together with differences in the chemical shifts, and nuclear Overhauser enhancement in the carbonyl, carboxyl, and alpha-carbon regions of the spectrum point to the vicinity of subsites D and E as the primary locus of the structural change.}, added-at = {2017-03-14T02:48:56.000+0100}, author = {Cozzone, P J and Opella, S J and Jardetzky, O and Berthou, J and Joll{\`{e}}s, P}, biburl = {https://www.bibsonomy.org/bibtex/23f60a4ef854ac870a99f02e43cc95e6c/nmrresource}, interhash = {40a94c054ee848f0d937d6123cbe2075}, intrahash = {3f60a4ef854ac870a99f02e43cc95e6c}, issn = {0027-8424}, journal = {Proc. Natl. Acad. Sci. U.S.A.}, keywords = {Carbon Conformation,Temperature,Tryptophan,Tyrosine Isotopes,Egg Resonance Spectroscopy,Muramidase,Protein White,Magnetic}, month = jun, number = 6, pages = {2095--2098}, pmid = {1056017}, timestamp = {2017-03-14T02:49:21.000+0100}, title = {{Detection of new temperature-dependent conformational transition in lysozyme by carbon-13 nuclear magnetic resonance spectroscopy}}, volume = 72, year = 1975 }