%0 Journal Article %1 Nagel.2003 %A Nagel, E. %A Vilser, W. %A Lanzl, I. M. %D 2003 %J Clinical hemorheology and microcirculation %K (Vasoconstrictor 0 Aged;Online Agents);Adult;Conjunctiva/*blood Agents/administration Systems;*Ophthalmoscopes;Ophthalmoscopy/methods;Retinal Vessels;Software;Vasoconstriction;Vasoconstrictor WViCo dosage/pharmacology;Vasodilation supply;Humans;Microcirculation;Middle {\&} %N 4 %P 221--227 %T Online human conjunctival vessel diameter analysis. A clinical-methodical study %V 28 %X BACKGROUND: The present study investigates the possible application of a commercially available on-line measuring device of retinal vessels for conjunctival vessel assessment. METHODS: Repeated measurements in one randomly chosen eye were performed in 11 healthy volunteers (mean age 42.9 +/- 10 years). Measurements of one conjunctival vessel were obtained first without a stimulus followed by measurements after the application of one drop of a topical vasoconstrictor. The examinations were performed by Retinal Vessel Analyzer (RVA, IMEDOS/Germany). This system determines automatically on-line the vessel diameter along a chosen vessel segment. RESULTS: Measurements in the native state without eye drop application showed an intraclass correlation coefficient of 0.97 and a mean variation coefficient of 1.8\%. After application of the topical vasoconstrictor a short acting vasodilatation was observed with a magnitude of +10.9\% +/- 14.9 (p < 0.001), followed by an increasing vasoconstriction (after 4 min -12.0\% +/- 7.6; p = 0.004). One volunteer had no measurable conjunctival vessels in the baseline measurements and was therefore excluded from the study. DISCUSSION: The suggested technique allows the measurement of changes in conjunctival vessel diameter with high precision. The method represents a non invasive technique for the assessment of effects on conjunctival vessels caused by topical or systemic drugs.

@article{Nagel.2003, abstract = {BACKGROUND: The present study investigates the possible application of a commercially available on-line measuring device of retinal vessels for conjunctival vessel assessment. METHODS: Repeated measurements in one randomly chosen eye were performed in 11 healthy volunteers (mean age 42.9 +/- 10 years). Measurements of one conjunctival vessel were obtained first without a stimulus followed by measurements after the application of one drop of a topical vasoconstrictor. The examinations were performed by Retinal Vessel Analyzer (RVA, IMEDOS/Germany). This system determines automatically on-line the vessel diameter along a chosen vessel segment. RESULTS: Measurements in the native state without eye drop application showed an intraclass correlation coefficient of 0.97 and a mean variation coefficient of 1.8{\%}. After application of the topical vasoconstrictor a short acting vasodilatation was observed with a magnitude of +10.9{\%} +/- 14.9 (p < 0.001), followed by an increasing vasoconstriction (after 4 min -12.0{\%} +/- 7.6; p = 0.004). One volunteer had no measurable conjunctival vessels in the baseline measurements and was therefore excluded from the study. DISCUSSION: The suggested technique allows the measurement of changes in conjunctival vessel diameter with high precision. The method represents a non invasive technique for the assessment of effects on conjunctival vessels caused by topical or systemic drugs.}, added-at = {2013-10-10T21:29:09.000+0200}, author = {Nagel, E. and Vilser, W. and Lanzl, I. M.}, biburl = {https://www.bibsonomy.org/bibtex/22c1a718f0bcf242cbcf0bdd3546bfad9/imedos}, interhash = {42e2df126b417c6f66cd206522c1f479}, intrahash = {2c1a718f0bcf242cbcf0bdd3546bfad9}, issn = {1386-0291}, journal = {Clinical hemorheology and microcirculation}, keywords = {(Vasoconstrictor 0 Aged;Online Agents);Adult;Conjunctiva/*blood Agents/administration Systems;*Ophthalmoscopes;Ophthalmoscopy/methods;Retinal Vessels;Software;Vasoconstriction;Vasoconstrictor WViCo dosage/pharmacology;Vasodilation supply;Humans;Microcirculation;Middle {\&}}, number = 4, pages = {221--227}, timestamp = {2013-10-11T01:11:02.000+0200}, title = {Online human conjunctival vessel diameter analysis. A clinical-methodical study}, volume = 28, year = 2003 }