%0 Journal Article %1 RN125 %A Garcia-Beltran, O. %A Mena, N. %A Yanez, O. %A Caballero, J. %A Vargas, V. %A Nunez, M.T. %A Cassels, B.K. %D 2013 %I 2013 Elsevier Masson SAS. %J European Journal of Medicinal Chemistry %K cells, chelatable chelators, chemosensor, deficiency, dqcauchile dynamics, fe2+ fe3+ fluorescent ion, iron, labile molecular probes, sensor, turn-off %P 60-63 %R 10.1016/j.ejmech.2013.06.022 %T Design, Synthesis and Cellular Dynamics Studies in Membranes of a New Coumarin-Based "Turn-Off" Fluorescent Probe Selective for Fe2+ %U /brokenurl#<Go to ISI>://WOS:000325121800007 %V 67 %X A new coumarin-based 'turn-off' fluorescent probe, 7-(diethylamino)-N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2-oxo-2H-chromene-3-carboxamide (AGD) was synthesized. This compound is highly selective for ferrous ions (Fe2+) and can reversibly detect them in aqueous medium. The probe localizes to the cell membrane in living cells, where it can detect changes in Fe2+ concentration. Molecular dynamics (MD) simulations indicate that AGD interacts with the lipid bilayer at the level of the glycerol moieties.

@article{RN125, abstract = {A new coumarin-based 'turn-off' fluorescent probe, 7-(diethylamino)-N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2-oxo-2H-chromene-3-carboxamide (AGD) was synthesized. This compound is highly selective for ferrous ions (Fe2+) and can reversibly detect them in aqueous medium. The probe localizes to the cell membrane in living cells, where it can detect changes in Fe2+ concentration. Molecular dynamics (MD) simulations indicate that AGD interacts with the lipid bilayer at the level of the glycerol moieties. }, added-at = {2019-12-04T03:57:35.000+0100}, author = {Garcia-Beltran, O. and Mena, N. and Yanez, O. and Caballero, J. and Vargas, V. and Nunez, M.T. and Cassels, B.K.}, biburl = {https://www.bibsonomy.org/bibtex/29fb92cdd454bfbe19ff4258f5e87ee76/dqcauchile}, doi = {10.1016/j.ejmech.2013.06.022}, interhash = {4f4b7a20e70ca5377a3fd3cd49a64925}, intrahash = {9fb92cdd454bfbe19ff4258f5e87ee76}, issn = {0223-5234}, journal = {European Journal of Medicinal Chemistry}, keywords = {cells, chelatable chelators, chemosensor, deficiency, dqcauchile dynamics, fe2+ fe3+ fluorescent ion, iron, labile molecular probes, sensor, turn-off}, pages = {60-63}, publisher = {2013 Elsevier Masson SAS.}, timestamp = {2019-12-04T03:58:17.000+0100}, title = {Design, Synthesis and Cellular Dynamics Studies in Membranes of a New Coumarin-Based "Turn-Off" Fluorescent Probe Selective for Fe2+}, type = {Journal Article}, url = {/brokenurl#<Go to ISI>://WOS:000325121800007}, volume = 67, year = 2013 }