%0 Journal Article %1 French2004 %A French, Noel P %A Hagan, Ronald %A Evans, Sharon F %A Mullan, Annie %A Newnham, John P %D 2004 %J Am J Obstet Gynecol %K Adrenal Cortex Hormones; Aging; Cerebral Palsy; Child Behavior; Child, Preschool; Cognition; Disability Evaluation; Drug Administration Schedule; Female; Humans; Hyperkinesis; Neuropsychological Tests; Pregnancy; Prenatal Care %N 3 %P 588--595 %R 10.1016/j.ajog.2003.12.016 %T Repeated antenatal corticosteroids: effects on cerebral palsy and childhood behavior. %U http://dx.doi.org/10.1016/j.ajog.2003.12.016 %V 190 %X OBJECTIVE: This study was undertaken to determine the effects of repeated courses of antenatal corticosteroids on childhood behavior and disabilities, including cognitive delay and cerebral palsy. STUDY DESIGN: Nonrandomized regional cohort of 541 very preterm infants born in Western Australia from singleton pregnancies and alive at 3 years were included in the study. MAIN OUTCOME MEASURES: Physical, cognitive, and psychological assessments up to 6 years. RESULTS: Increasing numbers of antenatal corticosteroid courses were associated with a reduction in the rate of cerebral palsy. Three or more courses were also associated with increased rates of aggressive/destructive, distractible, and hyperkinetic behavior and these effects were present at both ages 3 and 6 years. Measures of internalizing behavior and intelligence quotient were unaffected by antenatal corticosteroid use. CONCLUSION: Repeated antenatal courses of corticosteroids may protect against cerebral palsy but are associated with hyperactivity later in childhood.

@article{French2004, abstract = {OBJECTIVE: This study was undertaken to determine the effects of repeated courses of antenatal corticosteroids on childhood behavior and disabilities, including cognitive delay and cerebral palsy. STUDY DESIGN: Nonrandomized regional cohort of 541 very preterm infants born in Western Australia from singleton pregnancies and alive at 3 years were included in the study. MAIN OUTCOME MEASURES: Physical, cognitive, and psychological assessments up to 6 years. RESULTS: Increasing numbers of antenatal corticosteroid courses were associated with a reduction in the rate of cerebral palsy. Three or more courses were also associated with increased rates of aggressive/destructive, distractible, and hyperkinetic behavior and these effects were present at both ages 3 and 6 years. Measures of internalizing behavior and intelligence quotient were unaffected by antenatal corticosteroid use. CONCLUSION: Repeated antenatal courses of corticosteroids may protect against cerebral palsy but are associated with hyperactivity later in childhood.}, added-at = {2014-07-19T19:29:03.000+0200}, author = {French, Noel P and Hagan, Ronald and Evans, Sharon F and Mullan, Annie and Newnham, John P}, biburl = {https://www.bibsonomy.org/bibtex/2e3ecdb6e45d29a91bc3b89333123e108/ar0berts}, doi = {10.1016/j.ajog.2003.12.016}, groups = {public}, interhash = {5b39f415fc9c1088f732627a3654eb99}, intrahash = {e3ecdb6e45d29a91bc3b89333123e108}, journal = {Am J Obstet Gynecol}, keywords = {Adrenal Cortex Hormones; Aging; Cerebral Palsy; Child Behavior; Child, Preschool; Cognition; Disability Evaluation; Drug Administration Schedule; Female; Humans; Hyperkinesis; Neuropsychological Tests; Pregnancy; Prenatal Care}, month = Mar, number = 3, pages = {588--595}, pii = {S0002937803021410}, pmid = {15041985}, timestamp = {2014-07-19T19:29:03.000+0200}, title = {Repeated antenatal corticosteroids: effects on cerebral palsy and childhood behavior.}, url = {http://dx.doi.org/10.1016/j.ajog.2003.12.016}, username = {ar0berts}, volume = 190, year = 2004 }