%0 Journal Article %1 kyleReview1027Patients2003 %A Kyle, Robert A. %A Gertz, Morie A. %A Witzig, Thomas E. %A Lust, John A. %A Lacy, Martha Q. %A Dispenzieri, Angela %A Fonseca, Rafael %A Rajkumar, S. Vincent %A Offord, Janice R. %A Larson, Dirk R. %A Plevak, Matthew E. %A Therneau, Terry M. %A Greipp, Philip R. %D 2003 %J Mayo Clinic Proceedings %K 80 Adult, Aged, Albumin, Analysis Analysis, Anemia, Blood Cohort Count, Creatinine, Diagnosis, Differential, Electrophoresis, Female, Humans, Hypercalcemia, Immunoelectrophoresis, Male, Medical Middle Multiple Multivariate Myeloma, Paraproteinemias, Platelet Predictive Prognosis, Protein Records, Retrospective Serum Studies, Survival Tests, Value and of over, %N 1 %P 21--33 %R 10/bs57s4 %T Review of 1027 patients with newly diagnosed multiple myeloma %V 78 %X OBJECTIVE: To determine the clinical and laboratory features of newly diagnosed multiple myeloma. PATIENTS AND METHODS: Records of all patients in whom multiple myeloma was initially diagnosed at the Mayo Clinic in Rochester, Minn, from January 1, 1985, to December 31, 1998, were reviewed. RESULTS: Of the 1027 study patients, 2\% were younger than 40 years, and 38\% were 70 years or older. The median age was 66 years. Anemia was present initially in 73\% of patients, hypercalcemia (calcium level \textgreater or = 11 mg/dL) in 13\%, and a serum creatinine level of 2 mg/dL or more in 19\%. The beta2-microglobulin level was increased in 75\%. Serum protein electrophoresis revealed a localized band in 82\% of patients, and immunoelectrophoresis or immunofixation showed a monoclonal protein in 93\%. A monoclonal light chain was found in the urine in 78\%. Nonsecretory myeloma was recognized in 3\% of patients, whereas light-chain myeloma was present in 20\%. Conventional radiographs showed an abnormality in 79\%. The plasma cell labeling index was 1\% or more in 34\% of patients. Multivariate analysis revealed that age, plasma cell labeling index, low platelet count, serum albumin value, and the log of the creatinine value were the most important prognostic factors. CONCLUSION: The median duration of survival was 33 months and did not improve from 1985 through 1998.

@article{kyleReview1027Patients2003, abstract = {OBJECTIVE: To determine the clinical and laboratory features of newly diagnosed multiple myeloma. PATIENTS AND METHODS: Records of all patients in whom multiple myeloma was initially diagnosed at the Mayo Clinic in Rochester, Minn, from January 1, 1985, to December 31, 1998, were reviewed. RESULTS: Of the 1027 study patients, 2\% were younger than 40 years, and 38\% were 70 years or older. The median age was 66 years. Anemia was present initially in 73\% of patients, hypercalcemia (calcium level {\textgreater} or = 11 mg/dL) in 13\%, and a serum creatinine level of 2 mg/dL or more in 19\%. The beta2-microglobulin level was increased in 75\%. Serum protein electrophoresis revealed a localized band in 82\% of patients, and immunoelectrophoresis or immunofixation showed a monoclonal protein in 93\%. A monoclonal light chain was found in the urine in 78\%. Nonsecretory myeloma was recognized in 3\% of patients, whereas light-chain myeloma was present in 20\%. Conventional radiographs showed an abnormality in 79\%. The plasma cell labeling index was 1\% or more in 34\% of patients. Multivariate analysis revealed that age, plasma cell labeling index, low platelet count, serum albumin value, and the log of the creatinine value were the most important prognostic factors. CONCLUSION: The median duration of survival was 33 months and did not improve from 1985 through 1998.}, added-at = {2019-06-01T08:49:45.000+0200}, author = {Kyle, Robert A. and Gertz, Morie A. and Witzig, Thomas E. and Lust, John A. and Lacy, Martha Q. and Dispenzieri, Angela and Fonseca, Rafael and Rajkumar, S. Vincent and Offord, Janice R. and Larson, Dirk R. and Plevak, Matthew E. and Therneau, Terry M. and Greipp, Philip R.}, biburl = {https://www.bibsonomy.org/bibtex/24e3a5a8071a1af80c560162d5f54860e/djtlmd}, doi = {10/bs57s4}, interhash = {5b526d7a2c49824eeb6e33805588f668}, intrahash = {4e3a5a8071a1af80c560162d5f54860e}, issn = {0025-6196}, journal = {Mayo Clinic Proceedings}, keywords = {80 Adult, Aged, Albumin, Analysis Analysis, Anemia, Blood Cohort Count, Creatinine, Diagnosis, Differential, Electrophoresis, Female, Humans, Hypercalcemia, Immunoelectrophoresis, Male, Medical Middle Multiple Multivariate Myeloma, Paraproteinemias, Platelet Predictive Prognosis, Protein Records, Retrospective Serum Studies, Survival Tests, Value and of over,}, language = {eng}, month = jan, note = {00000 }, number = 1, pages = {21--33}, pmid = {12528874}, timestamp = {2019-06-01T08:49:45.000+0200}, title = {Review of 1027 patients with newly diagnosed multiple myeloma}, volume = 78, year = 2003 }