Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters.
J. Gotter, B. Brors, M. Hergenhahn, and B. Kyewski.
J Exp Med 199 (2): 155--166 (January 2004)

Promiscuous expression of tissue-specific self-antigens in the thymus imposes T cell tolerance and protects from autoimmune diseases, as shown in animal studies. Analysis of promiscuous gene expression in purified stromal cells of the human thymus at the single and global gene level documents the species conservation of this phenomenon. Medullary thymic epithelial cells overexpress a highly diverse set of genes (>400) including many tissue-specific antigens, disease-associated autoantigens, and cancer-germline genes. Although there are no apparent structural or functional commonalities among these genes and their products, they cluster along chromosomes. These findings have implications for human autoimmune diseases, immuno-therapy of tumors, and the understanding of the nature of this unorthodox regulation of gene expression.

URL: http://dx.doi.org/10.1084/jem.20031677
DOI: 10.1084/jem.20031677
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@article{Gotter2004,
  __markedentry = {[bbrors:6]},
  abstract = {Promiscuous expression of tissue-specific self-antigens in the thymus imposes T cell tolerance and protects from autoimmune diseases, as shown in animal studies. Analysis of promiscuous gene expression in purified stromal cells of the human thymus at the single and global gene level documents the species conservation of this phenomenon. Medullary thymic epithelial cells overexpress a highly diverse set of genes (>400) including many tissue-specific antigens, disease-associated autoantigens, and cancer-germline genes. Although there are no apparent structural or functional commonalities among these genes and their products, they cluster along chromosomes. These findings have implications for human autoimmune diseases, immuno-therapy of tumors, and the understanding of the nature of this unorthodox regulation of gene expression.},
  added-at = {2015-04-09T12:36:21.000+0200},
  author = {Gotter, J{\"{o}}rn and Brors, Benedikt and Hergenhahn, Manfred and Kyewski, Bruno},
  biburl = {https://www.bibsonomy.org/bibtex/2f4cef395fbf24768eb6669eeba1dddb0/bbrors},
  doi = {10.1084/jem.20031677},
  institution = {Tumor Immunology Program, German Cancer Research Center, Heidelberg, Germany.},
  interhash = {5f399b7f1b7593bd93f43b3e9902e0a9},
  intrahash = {f4cef395fbf24768eb6669eeba1dddb0},
  journal = {J Exp Med},
  keywords = {Animals; Autoantigens, Autoimmunity, Base Cells, Chromosomes, Conserved DNA Epithelial Expression; Family; Female; Gene Gland, Human, Humans; Infant; Male; Mice; Multigene Primers, RNA, Self Sequence; Species Specificity; T-Lymphocytes, Thymus Tolerance, cytology/immunology genetics; immunology;},
  language = {eng},
  medline-pst = {ppublish},
  month = Jan,
  number = 2,
  owner = {bbrors},
  pages = {155--166},
  pii = {jem.20031677},
  pmid = {14734521},
  timestamp = {2015-04-09T12:36:21.000+0200},
  title = {Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters.},
  url = {http://dx.doi.org/10.1084/jem.20031677},
  volume = 199,
  year = 2004
}

%0 Journal Article
%1 Gotter2004
%A Gotter, Jörn
%A Brors, Benedikt
%A Hergenhahn, Manfred
%A Kyewski, Bruno
%D 2004
%J J Exp Med
%K Animals; Autoantigens, Autoimmunity, Base Cells, Chromosomes, Conserved DNA Epithelial Expression; Family; Female; Gene Gland, Human, Humans; Infant; Male; Mice; Multigene Primers, RNA, Self Sequence; Species Specificity; T-Lymphocytes, Thymus Tolerance, cytology/immunology genetics; immunology;
%N 2
%P 155--166
%R 10.1084/jem.20031677
%T Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters.
%U http://dx.doi.org/10.1084/jem.20031677
%V 199
%X Promiscuous expression of tissue-specific self-antigens in the thymus imposes T cell tolerance and protects from autoimmune diseases, as shown in animal studies. Analysis of promiscuous gene expression in purified stromal cells of the human thymus at the single and global gene level documents the species conservation of this phenomenon. Medullary thymic epithelial cells overexpress a highly diverse set of genes (>400) including many tissue-specific antigens, disease-associated autoantigens, and cancer-germline genes. Although there are no apparent structural or functional commonalities among these genes and their products, they cluster along chromosomes. These findings have implications for human autoimmune diseases, immuno-therapy of tumors, and the understanding of the nature of this unorthodox regulation of gene expression.

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Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters.
J. Gotter, B. Brors, M. Hergenhahn, and B. Kyewski.
J Exp Med 199 (2): 155--166 (January 2004)

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Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters.J. Gotter, B. Brors, M. Hergenhahn, and B. Kyewski. J Exp Med 199 (2): 155--166 (January 2004)

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Cite this publication

Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters.
J. Gotter, B. Brors, M. Hergenhahn, and B. Kyewski.
J Exp Med 199 (2): 155--166 (January 2004)