%0 Journal Article %1 wang2012hyaluronic %A Wang, Xiumei %A He, Jin %A Wang, Ying %A Cui, Fu-Zhai %D 2012 %J Interface Focus %K biomaterial phd review scaffold %N 3 %P 278--291 %R 10.1098/rsfs.2012.0016 %T Hyaluronic acid-based scaffold for central neural tissue engineering %U http://rsfs.royalsocietypublishing.org/content/2/3/278.abstract %V 2 %X Central nervous system (CNS) regeneration with central neuronal connections and restoration of synaptic connections has been a long-standing worldwide problem and, to date, no effective clinical therapies are widely accepted for CNS injuries. The limited regenerative capacity of the CNS results from the growth-inhibitory environment that impedes the regrowth of axons. Central neural tissue engineering has attracted extensive attention from multi-disciplinary scientists in recent years, and many studies have been carried out to develop cell- and regeneration-activating biomaterial scaffolds that create an artificial micro-environment suitable for axonal regeneration. Among all the biomaterials, hyaluronic acid (HA) is a promising candidate for central neural tissue engineering because of its unique physico-chemical and biological properties. This review attempts to outline current biomaterials-based strategies for CNS regeneration from a tissue engineering point of view and discusses the main progresses in research of HA-based scaffolds for central neural tissue engineering in detail.

@article{wang2012hyaluronic, abstract = {Central nervous system (CNS) regeneration with central neuronal connections and restoration of synaptic connections has been a long-standing worldwide problem and, to date, no effective clinical therapies are widely accepted for CNS injuries. The limited regenerative capacity of the CNS results from the growth-inhibitory environment that impedes the regrowth of axons. Central neural tissue engineering has attracted extensive attention from multi-disciplinary scientists in recent years, and many studies have been carried out to develop cell- and regeneration-activating biomaterial scaffolds that create an artificial micro-environment suitable for axonal regeneration. Among all the biomaterials, hyaluronic acid (HA) is a promising candidate for central neural tissue engineering because of its unique physico-chemical and biological properties. This review attempts to outline current biomaterials-based strategies for CNS regeneration from a tissue engineering point of view and discusses the main progresses in research of HA-based scaffolds for central neural tissue engineering in detail.}, added-at = {2013-10-23T10:21:18.000+0200}, author = {Wang, Xiumei and He, Jin and Wang, Ying and Cui, Fu-Zhai}, biburl = {https://www.bibsonomy.org/bibtex/217bcbae9cb0b17fc831f3efc66b7f36e/bkoch}, description = {Hyaluronic acid-based scaffold for central neural tissue engineering}, doi = {10.1098/rsfs.2012.0016}, eprint = {http://rsfs.royalsocietypublishing.org/content/2/3/278.full.pdf+html}, interhash = {60f1b1a1729cce6a7007d991da22d17e}, intrahash = {17bcbae9cb0b17fc831f3efc66b7f36e}, journal = {Interface Focus}, keywords = {biomaterial phd review scaffold}, number = 3, pages = {278--291}, timestamp = {2013-10-23T10:21:18.000+0200}, title = {Hyaluronic acid-based scaffold for central neural tissue engineering}, url = {http://rsfs.royalsocietypublishing.org/content/2/3/278.abstract}, volume = 2, year = 2012 }