%0 Journal Article %1 he2012scaffolds %A He, Jin %A Wang, Xiu-Mei %A Spector, Myron %A Cui, Fu-Zhai %D 2012 %I SP Higher Education Press %J Frontiers of Materials Science %K biomaterial phd scaffold todo transplantation %N 1 %P 1--25 %R 10.1007/s11706-012-0157-5 %T Scaffolds for central nervous system tissue engineering %U http://dx.doi.org/10.1007/s11706-012-0157-5 %V 6 %X Traumatic injuries to the brain and spinal cord of the central nervous system (CNS) lead to severe and permanent neurological deficits and to date there is no universally accepted treatment. Owing to the profound impact, extensive studies have been carried out aiming at reducing inflammatory responses and overcoming the inhibitory environment in the CNS after injury so as to enhance regeneration. Artificial scaffolds may provide a suitable environment for axonal regeneration and functional recovery, and are of particular importance in cases in which the injury has resulted in a cavitary defect. In this review we discuss development of scaffolds for CNS tissue engineering, focusing on mechanism of CNS injuries, various biomaterials that have been used in studies, and current strategies for designing and fabricating scaffolds.

@article{he2012scaffolds, abstract = {Traumatic injuries to the brain and spinal cord of the central nervous system (CNS) lead to severe and permanent neurological deficits and to date there is no universally accepted treatment. Owing to the profound impact, extensive studies have been carried out aiming at reducing inflammatory responses and overcoming the inhibitory environment in the CNS after injury so as to enhance regeneration. Artificial scaffolds may provide a suitable environment for axonal regeneration and functional recovery, and are of particular importance in cases in which the injury has resulted in a cavitary defect. In this review we discuss development of scaffolds for CNS tissue engineering, focusing on mechanism of CNS injuries, various biomaterials that have been used in studies, and current strategies for designing and fabricating scaffolds.}, added-at = {2013-11-06T10:58:47.000+0100}, author = {He, Jin and Wang, Xiu-Mei and Spector, Myron and Cui, Fu-Zhai}, biburl = {https://www.bibsonomy.org/bibtex/226ba1c65f87a0de451702b1dbe8cb737/bkoch}, description = {Scaffolds for central nervous system tissue engineering - Springer}, doi = {10.1007/s11706-012-0157-5}, interhash = {67d7fa9326926e604e4639415cc2f9df}, intrahash = {26ba1c65f87a0de451702b1dbe8cb737}, issn = {2095-025X}, journal = {Frontiers of Materials Science}, keywords = {biomaterial phd scaffold todo transplantation}, language = {English}, number = 1, pages = {1--25}, publisher = {SP Higher Education Press}, timestamp = {2013-11-06T10:58:47.000+0100}, title = {Scaffolds for central nervous system tissue engineering}, url = {http://dx.doi.org/10.1007/s11706-012-0157-5}, volume = 6, year = 2012 }