%0 Journal Article %1 hoiseth_multi-country_2013 %A Hoiseth, Susan K %A Murphy, Ellen %A Andrew, Lubomira %A Vogel, Ulrich %A Frosch, Matthias %A Hellenbrand, Wiebke %A Abad, Raquel %A Vazquez, Julio A %A Borrow, Ray %A Findlow, Jamie %A Taha, Muhamed-Kheir %A Deghmane, Ala-Eddine %A Caugant, Dominique A %A Kriz, Paula %A Musilek, Martin %A Mayer, Leonard W %A Wang, Xin %A Macneil, Jessica R %A York, Laura %A Tan, Charles Y %A Jansen, Kathrin U %A Anderson, Annaliesa S %D 2013 %J The Pediatric infectious disease journal %K molecular_epidemiology %N 10 %P 1096--1101 %R 10.1097/INF.0b013e31829aa63b %T A Multi-country Evaluation of Neisseria meningitidis Serogroup B Factor H-Binding Proteins and Implications for Vaccine Coverage in Different Age Groups %V 32 %X BACKGROUND:: Recombinant vaccines containing factor H-binding protein (fHBP) have been developed for the purpose of protection from invasive meningococcal serogroup B disease. Neisseria meningitidis fHBP sequences can be divided into 2 genetically and immunologically distinct subfamilies (A and B); thus, cross protection is conferred within but not between subfamilies. A comprehensive understanding of fHBP epidemiology is required to accurately assess the potential vaccine impact when considering different vaccination implementation strategies. METHODS:: Systematically collected invasive meningococcal serogroup B isolates from England, Wales, Northern Ireland, the United States, Norway, France and the Czech Republic were previously characterized for fHBP sequence. This study expanded the evaluation with additional meningococcal serogroup B disease isolates from Spain (n = 346) and Germany (n = 205). This expanded set (n = 1841), collected over a 6-year period (2001 to 2006), was evaluated for fHBP sequence and fHBP subfamily relative to patient age. RESULTS:: All 1841 isolates contained fhbp. fHBP sequences from Spain and Germany fell within the previously described subfamilies, with 69\% of isolates belonging to subfamily B and 31\% to subfamily A; prevalent sequence variants were also similar. Stratification of data by age indicated that disease in infants \textless1 year of age was caused by a significantly higher proportion of isolates with fHBP subfamily A variants than that seen in adolescents and young adults 11-25 years (47.7\% versus 19.5\%, P \textless 0.0001, respectively). CONCLUSIONS:: These observations highlight a difference in epidemiology of fHBP subfamilies in different age groups, with fHBP subfamily A strains causing more disease in vulnerable populations, such as infants, than in adolescents.

@article{hoiseth_multi-country_2013, abstract = {{BACKGROUND::} Recombinant vaccines containing factor H-binding protein ({fHBP)} have been developed for the purpose of protection from invasive meningococcal serogroup B disease. Neisseria meningitidis {fHBP} sequences can be divided into 2 genetically and immunologically distinct subfamilies (A and B); thus, cross protection is conferred within but not between subfamilies. A comprehensive understanding of {fHBP} epidemiology is required to accurately assess the potential vaccine impact when considering different vaccination implementation strategies. {METHODS::} Systematically collected invasive meningococcal serogroup B isolates from England, Wales, Northern Ireland, the United States, Norway, France and the Czech Republic were previously characterized for {fHBP} sequence. This study expanded the evaluation with additional meningococcal serogroup B disease isolates from Spain (n = 346) and Germany (n = 205). This expanded set (n = 1841), collected over a 6-year period (2001 to 2006), was evaluated for {fHBP} sequence and {fHBP} subfamily relative to patient age. {RESULTS::} All 1841 isolates contained fhbp. {fHBP} sequences from Spain and Germany fell within the previously described subfamilies, with 69\% of isolates belonging to subfamily B and 31\% to subfamily A; prevalent sequence variants were also similar. Stratification of data by age indicated that disease in infants {\textless}1 year of age was caused by a significantly higher proportion of isolates with {fHBP} subfamily A variants than that seen in adolescents and young adults 11-25 years (47.7\% versus 19.5\%, P {\textless} 0.0001, respectively). {CONCLUSIONS::} These observations highlight a difference in epidemiology of {fHBP} subfamilies in different age groups, with {fHBP} subfamily A strains causing more disease in vulnerable populations, such as infants, than in adolescents.}, added-at = {2013-10-04T09:46:01.000+0200}, author = {Hoiseth, Susan K and Murphy, Ellen and Andrew, Lubomira and Vogel, Ulrich and Frosch, Matthias and Hellenbrand, Wiebke and Abad, Raquel and Vazquez, Julio A and Borrow, Ray and Findlow, Jamie and Taha, Muhamed-Kheir and Deghmane, Ala-Eddine and Caugant, Dominique A and Kriz, Paula and Musilek, Martin and Mayer, Leonard W and Wang, Xin and Macneil, Jessica R and York, Laura and Tan, Charles Y and Jansen, Kathrin U and Anderson, Annaliesa S}, biburl = {https://www.bibsonomy.org/bibtex/205962600fc15529ea9758b373369f713/ag_vogel}, doi = {10.1097/INF.0b013e31829aa63b}, interhash = {6f430a23e90bbba7cb2eb753551df396}, intrahash = {05962600fc15529ea9758b373369f713}, issn = {1532-0987}, journal = {The Pediatric infectious disease journal}, keywords = {molecular_epidemiology}, language = {{ENG}}, month = oct, note = {{PMID:} 23694830}, number = 10, pages = {1096--1101}, timestamp = {2013-10-04T09:51:57.000+0200}, title = {A Multi-country Evaluation of Neisseria meningitidis Serogroup B Factor H-Binding Proteins and Implications for Vaccine Coverage in Different Age Groups}, volume = 32, year = 2013 }