%0 Journal Article %1 WOS:000465059600018 %A Alexandrino, F J R %A Bezerra, E M %A Costa, R F Da %A Cavalcante, L R L %A Sales, F A M %A Francisco, T S %A Rodrigues, L K A %A de Brito, D H Almeida %A Ricardo, N M P S %A Costa, S N %A de Lima-Neto, P %A Barroso-Neto, I L %A Caetano, E W S %A Freire, V N %C PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS %D 2019 %I ELSEVIER SCIENCE BV %J PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY %K Antibacterial Antimicrobial Bengal; Molecular Photodynamic activity; alpha-cyclodextrin interaction microparticles; photodynamic simulations; therapy; therapy} {Rose %P 111-118 %R 10.1016/j.pdpdt.2018.11.016 %T Rose Bengal incorporated to alpha-cyclodextrin microparticles for photodynamic therapy against the cariogenic microorganism Streptococcus mutans %V 25 %X Rose Bengal@alpha-cyclodextrin (RB@alpha-CD) microparticles (mu Ps) were prepared and the RB inclusion in alpha-CD was experimentally demonstrated through infrared, UV-VIS absorption spectroscopy and cyclic voltammetry. The RB inclusion in alpha-CD was theoretically investigated using classical molecular mechanics calculations, the simulation results showing that RB can be included in both the narrow and wide apertures of the alpha-cyclodextrin ring with configurations exhibiting average binding energies of about 27 kcal mol(-1). The prepared RB@alpha-CD microparticles were characterized through Scanning Electron Microscopy (SEM) and it was demonstrated that they are highly efficient in the photodynamic therapy against a Streptococcus mutans (the main bacteria of cariogenic dental plaque) suspension, as a concentration of RB@alpha-CD mu Ps 10 times smaller than the usual concentration of pure RB is still capable to produce significant antibacterial activity.

@article{WOS:000465059600018, abstract = {Rose Bengal@alpha-cyclodextrin (RB@alpha-CD) microparticles (mu Ps) were prepared and the RB inclusion in alpha-CD was experimentally demonstrated through infrared, UV-VIS absorption spectroscopy and cyclic voltammetry. The RB inclusion in alpha-CD was theoretically investigated using classical molecular mechanics calculations, the simulation results showing that RB can be included in both the narrow and wide apertures of the alpha-cyclodextrin ring with configurations exhibiting average binding energies of about 27 kcal mol(-1). The prepared RB@alpha-CD microparticles were characterized through Scanning Electron Microscopy (SEM) and it was demonstrated that they are highly efficient in the photodynamic therapy against a Streptococcus mutans (the main bacteria of cariogenic dental plaque) suspension, as a concentration of RB@alpha-CD mu Ps 10 times smaller than the usual concentration of pure RB is still capable to produce significant antibacterial activity.}, added-at = {2022-05-23T20:00:14.000+0200}, address = {PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS}, author = {Alexandrino, F J R and Bezerra, E M and Costa, R F Da and Cavalcante, L R L and Sales, F A M and Francisco, T S and Rodrigues, L K A and de Brito, D H Almeida and Ricardo, N M P S and Costa, S N and de Lima-Neto, P and Barroso-Neto, I L and Caetano, E W S and Freire, V N}, biburl = {https://www.bibsonomy.org/bibtex/2136be607f320fecf920f897b871194d2/ppgfis_ufc_br}, doi = {10.1016/j.pdpdt.2018.11.016}, interhash = {707e53967a286c1fb24cf6257351152e}, intrahash = {136be607f320fecf920f897b871194d2}, issn = {1572-1000}, journal = {PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY}, keywords = {Antibacterial Antimicrobial Bengal; Molecular Photodynamic activity; alpha-cyclodextrin interaction microparticles; photodynamic simulations; therapy; therapy} {Rose}, pages = {111-118}, publisher = {ELSEVIER SCIENCE BV}, pubstate = {published}, timestamp = {2022-05-23T20:00:14.000+0200}, title = {Rose Bengal incorporated to alpha-cyclodextrin microparticles for photodynamic therapy against the cariogenic microorganism Streptococcus mutans}, tppubtype = {article}, volume = 25, year = 2019 }