%0 Journal Article %1 Walsh2013 %A Walsh, Edward E. %A Peterson, Derick R. %A Kalkanoglu, Aja E. %A Lee, Frances Eun-Hyung %A Falsey, Ann R. %D 2013 %J J Infect Dis %K virus facs immunization tlymphocytes %N 9 %P 1424--1432 %R 10.1093/infdis/jit038 %T Viral shedding and immune responses to respiratory syncytial virus infection in older adults. %U http://dx.doi.org/10.1093/infdis/jit038 %V 207 %X Comprehensive analyses of host, viral, and immune factors associated with severe respiratory syncytial virus (RSV) infection in adults have not been performed.Adults with RSV infection identified in both outpatient and inpatient settings were evaluated. Upper and lower respiratory tract virus load, duration of virus shedding, select mucosal chemokine and cytokine levels, humoral and mucosal immunoglobulin responses, and systemic T-cell responses were measured.A total of 111 RSV-infected adults (61 outpatients and 50 hospitalized patients) were evaluated. Hospitalized subjects shed virus in nasal secretions at higher titers and for longer durations than less ill outpatients, had greater mucosal interleukin 6 (IL-6) levels throughout infection, and had higher macrophage inflammatory protein 1α (MIP-1α) levels early in infection. Persons >64 years old and those with more severe disease had a higher frequency of activated T cells in the blood than younger, less ill subjects at infection. Multivariate analysis found that the presence of underlying medical conditions, female sex, increased mucosal IL-6 level, and longer duration of virus shedding were associated with severe disease. Older age and increased nasal MIP-1α levels were of borderline statistical significance.Multiple factors, but not older age, are independently associated with severe RSV infection in adults. The presence of underlying medical conditions had the greatest influence on disease severity.

@article{Walsh2013, abstract = {Comprehensive analyses of host, viral, and immune factors associated with severe respiratory syncytial virus (RSV) infection in adults have not been performed.Adults with RSV infection identified in both outpatient and inpatient settings were evaluated. Upper and lower respiratory tract virus load, duration of virus shedding, select mucosal chemokine and cytokine levels, humoral and mucosal immunoglobulin responses, and systemic T-cell responses were measured.A total of 111 RSV-infected adults (61 outpatients and 50 hospitalized patients) were evaluated. Hospitalized subjects shed virus in nasal secretions at higher titers and for longer durations than less ill outpatients, had greater mucosal interleukin 6 (IL-6) levels throughout infection, and had higher macrophage inflammatory protein 1α (MIP-1α) levels early in infection. Persons >64 years old and those with more severe disease had a higher frequency of activated T cells in the blood than younger, less ill subjects at infection. Multivariate analysis found that the presence of underlying medical conditions, female sex, increased mucosal IL-6 level, and longer duration of virus shedding were associated with severe disease. Older age and increased nasal MIP-1α levels were of borderline statistical significance.Multiple factors, but not older age, are independently associated with severe RSV infection in adults. The presence of underlying medical conditions had the greatest influence on disease severity.}, added-at = {2013-06-08T03:57:29.000+0200}, author = {Walsh, Edward E. and Peterson, Derick R. and Kalkanoglu, Aja E. and Lee, Frances Eun-Hyung and Falsey, Ann R.}, biburl = {https://www.bibsonomy.org/bibtex/20e4b8c5cb0843940be00d2cda46f5962/aorchid}, description = {have on paper from JID. Some flow shots demonstrating increased CD38 & DR expression on elderly compared with yound and healthy, as well as increased Ki-67+Bcl-2-. >90% of the 38/DR+ cells were Ki-67+Bcl-2-. Did not differentiate between RSV specific activation or not. Did not look at functional capacity.}, doi = {10.1093/infdis/jit038}, groups = {public}, institution = {Department of Medicine, University of Rochester School of Medicine and Dentistry, New York, USA. edward.walsh@rochestergeneral.org}, interhash = {724767fee0865ea3b6d32d136b053793}, intrahash = {0e4b8c5cb0843940be00d2cda46f5962}, journal = {J Infect Dis}, keywords = {virus facs immunization tlymphocytes}, language = {eng}, medline-pst = {ppublish}, month = May, number = 9, pages = {1424--1432}, pii = {jit038}, pmid = {23382572}, timestamp = {2013-06-08T03:59:14.000+0200}, title = {Viral shedding and immune responses to respiratory syncytial virus infection in older adults.}, url = {http://dx.doi.org/10.1093/infdis/jit038}, username = {aorchid}, volume = 207, year = 2013 }