%0 Journal Article %1 Salokorpi1997 %A Salokorpi, T. %A Sajaniemi, N. %A H?llback, H. %A Kari, A. %A Rita, H. %A von Wendt, L. %D 1997 %J Acta Paediatr %K Brain Diseases; Cerebral Palsy; Developmental Disabilities; Dexamethasone; Female; Finland; Follow-Up Studies; Glucocorticoids; Humans; Incidence; Infant, Newborn; Premature; Male; Placebos; Pregnancy; Prenatal Care; Retrospective Studies %N 3 %P 294--298 %T Randomized study of the effect of antenatal dexamethasone on growth and development of premature children at the corrected age of 2 years. %V 86 %X The objective of the series was to study the effect of prenatal dexamethasone therapy on the growth and neurological development of preterm children until the age of 2 years. Eighty-two children with a mean gestational age of 30 (24-33) weeks and a mean weight of 1291 (530-2360) g at birth, treated antenatally with either dexamethasone (n = 50) or placebo (n = 32), were examined at the adjusted age of 24 months by a paediatric neurologist, a neuropsychologist and a speech therapist. Neurological development was defined as normal if all scores of neuropaediatric, neuropsychological and verbal tests were within the normal range. Normal neurological development was found in 52\% of the dexamethasone-treated and in 34\% of the placebo-treated children. The incidence of cerebral palsy was 10\% in the dexamethasone group and 22\% in the placebo group. Minor developmental delay was found in 42\% of dexamethasone-treated and in 53\% of placebo-treated children. Our follow-up results indicate that the beneficial effect of prenatal glucocorticoid treatment on cerebral complications (intraventricular haemorrhage or periventricular leucomalacia) demonstrated during the neonatal period may be followed by a lower incidence of cerebral palsy in surviving premature children.

@article{Salokorpi1997, abstract = {The objective of the series was to study the effect of prenatal dexamethasone therapy on the growth and neurological development of preterm children until the age of 2 years. Eighty-two children with a mean gestational age of 30 (24-33) weeks and a mean weight of 1291 (530-2360) g at birth, treated antenatally with either dexamethasone (n = 50) or placebo (n = 32), were examined at the adjusted age of 24 months by a paediatric neurologist, a neuropsychologist and a speech therapist. Neurological development was defined as normal if all scores of neuropaediatric, neuropsychological and verbal tests were within the normal range. Normal neurological development was found in 52\% of the dexamethasone-treated and in 34\% of the placebo-treated children. The incidence of cerebral palsy was 10\% in the dexamethasone group and 22\% in the placebo group. Minor developmental delay was found in 42\% of dexamethasone-treated and in 53\% of placebo-treated children. Our follow-up results indicate that the beneficial effect of prenatal glucocorticoid treatment on cerebral complications (intraventricular haemorrhage or periventricular leucomalacia) demonstrated during the neonatal period may be followed by a lower incidence of cerebral palsy in surviving premature children.}, added-at = {2014-07-19T21:12:26.000+0200}, author = {Salokorpi, T. and Sajaniemi, N. and H?llback, H. and Kari, A. and Rita, H. and von Wendt, L.}, biburl = {https://www.bibsonomy.org/bibtex/2cfb52101ec5bddd93cd061109570e795/ar0berts}, groups = {public}, interhash = {7360d5cf1deb6694b2f29bec79750fd6}, intrahash = {cfb52101ec5bddd93cd061109570e795}, journal = {Acta Paediatr}, keywords = {Brain Diseases; Cerebral Palsy; Developmental Disabilities; Dexamethasone; Female; Finland; Follow-Up Studies; Glucocorticoids; Humans; Incidence; Infant, Newborn; Premature; Male; Placebos; Pregnancy; Prenatal Care; Retrospective Studies}, month = Mar, number = 3, pages = {294--298}, pmid = {9099320}, timestamp = {2014-07-19T21:12:26.000+0200}, title = {Randomized study of the effect of antenatal dexamethasone on growth and development of premature children at the corrected age of 2 years.}, username = {ar0berts}, volume = 86, year = 1997 }