Zusammenfassung
The import of many proteins into the nucleus is mediated by the importin-α/β heterodimer. While only one importin-β gene has been found, several forms of importin-α have been described. In addition to the three human importin-αs already identified, we report here the primary structure of two new human importin-α proteins. The five known human importin-α subunits can be classified into three subfamilies that appear conserved in higher eukaryotic organisms. We show by immunoblotting that the different importin-α subfamilies are expressed in a variety of human tissues and mammalian cell lines.
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