%0 Journal Article %1 vilar2003modeling %A Vilar, J M %A Guet, C C %A Leibler, S %D 2003 %J J Cell Biol %K differential_equations gene_regulation lac_operon modeling network_dynamics network_structure %N 3 %P 471-476 %R 10.1083/jcb.200301125 %T Modeling network dynamics: the lac operon, a case study %U https://www.ncbi.nlm.nih.gov/pubmed/12743100 %V 161 %X We use the lac operon in Escherichia coli as a prototype system to illustrate the current state, applicability, and limitations of modeling the dynamics of cellular networks. We integrate three different levels of description (molecular, cellular, and that of cell population) into a single model, which seems to capture many experimental aspects of the system.

@article{vilar2003modeling, abstract = {We use the lac operon in Escherichia coli as a prototype system to illustrate the current state, applicability, and limitations of modeling the dynamics of cellular networks. We integrate three different levels of description (molecular, cellular, and that of cell population) into a single model, which seems to capture many experimental aspects of the system.}, added-at = {2019-04-05T22:17:01.000+0200}, author = {Vilar, J M and Guet, C C and Leibler, S}, biburl = {https://www.bibsonomy.org/bibtex/2f4ba0f6bb908131b9b5cd88e2a23eaae/peter.ralph}, doi = {10.1083/jcb.200301125}, interhash = {785a88d0e8f5ac0242f9f26ff5a09c0c}, intrahash = {f4ba0f6bb908131b9b5cd88e2a23eaae}, journal = {J Cell Biol}, keywords = {differential_equations gene_regulation lac_operon modeling network_dynamics network_structure}, month = may, number = 3, pages = {471-476}, pmid = {12743100}, timestamp = {2019-04-06T01:55:24.000+0200}, title = {Modeling network dynamics: the lac operon, a case study}, url = {https://www.ncbi.nlm.nih.gov/pubmed/12743100}, volume = 161, year = 2003 }