%0 Journal Article %1 Ande_2006_81 %A Anderson, M. E. %D 2006 %J J. Intern. Med. %K 16336516 AMP-Dependent Action Arrhythmia, Biological, Calcium Calcium, Cardiomyopathies, Channel, Channels, Congestive, Cyclic Dependent Extramural, Failure, Gov't, Heart Heart, Homeostasis, Humans, Kinase, Kinases, L-Type, Long Models, Myocardium, N.I.H., Non-U.S. Potentials, Protein QT Receptor Release Research Reticulum, Ryanodine Sarcoplasmic Support, Syndrome, {C}a$^{2+}$-Calmodulin %N 1 %P 81--90 %R 10.1111/j.1365-2796.2005.01580.x %T QT interval prolongation and arrhythmia: an unbreakable connection? %U http://dx.doi.org/10.1111/j.1365-2796.2005.01580.x %V 259 %X QT interval prolongation is incontrovertibly linked to increased risk of arrhythmias but, paradoxically, QT interval prolongation can also be an effective antiarrhythmic strategy and is in fact the goal of class III antiarrhythmic drugs. This discussion examines the cellular effects of QT interval prolongation and proposes that calmodulin kinase II (CaMKII) is a specific cellular proarrhythmic signal that is activated downstream to QT interval prolongation. Inhibition of CaMKII can prevent cellular arrhythmia surrogates and in vivo arrhythmias linked to excessive action potential prolongation, suggesting that QT interval prolongation alone does not fully account for proarrhythmia. This reasoning points to the conclusion that QT interval modulation and prolongation not only grades cellular Ca$^2+$ entry for cardiac contraction but also has the potential to recruit Ca$^2+$-activated signalling molecules. CaMKII is one of these molecules and CaMKII activity is at least partially responsible for the proarrhythmic consequences of excessive QT interval prolongation.

@article{Ande_2006_81, abstract = {QT interval prolongation is incontrovertibly linked to increased risk of arrhythmias but, paradoxically, QT interval prolongation can also be an effective antiarrhythmic strategy and is in fact the goal of class III antiarrhythmic drugs. This discussion examines the cellular effects of QT interval prolongation and proposes that calmodulin kinase II (CaMKII) is a specific cellular proarrhythmic signal that is activated downstream to QT interval prolongation. Inhibition of CaMKII can prevent cellular arrhythmia surrogates and in vivo arrhythmias linked to excessive action potential prolongation, suggesting that QT interval prolongation alone does not fully account for proarrhythmia. This reasoning points to the conclusion that QT interval modulation and prolongation not only grades cellular {C}a$^{2+}$ entry for cardiac contraction but also has the potential to recruit {C}a$^{2+}$-activated signalling molecules. CaMKII is one of these molecules and CaMKII activity is at least partially responsible for the proarrhythmic consequences of excessive QT interval prolongation.}, added-at = {2009-06-03T11:20:58.000+0200}, author = {Anderson, M. E.}, biburl = {https://www.bibsonomy.org/bibtex/297ef3607fa4c1357eaec58a7429344da/hake}, description = {The whole bibliography file I use.}, doi = {10.1111/j.1365-2796.2005.01580.x}, file = {Ande_2006_81.pdf:Ande_2006_81.pdf:PDF}, interhash = {7a9f863b179ffcef1f2c0b4b480c770d}, intrahash = {97ef3607fa4c1357eaec58a7429344da}, journal = {J. Intern. Med.}, key = 285, keywords = {16336516 AMP-Dependent Action Arrhythmia, Biological, Calcium Calcium, Cardiomyopathies, Channel, Channels, Congestive, Cyclic Dependent Extramural, Failure, Gov't, Heart Heart, Homeostasis, Humans, Kinase, Kinases, L-Type, Long Models, Myocardium, N.I.H., Non-U.S. Potentials, Protein QT Receptor Release Research Reticulum, Ryanodine Sarcoplasmic Support, Syndrome, {C}a$^{2+}$-Calmodulin}, month = Jan, number = 1, pages = {81--90}, pdf = {Ande_2006_81.pdf}, pii = {JIM1580}, pmid = {16336516}, timestamp = {2009-06-03T11:21:00.000+0200}, title = {QT interval prolongation and arrhythmia: an unbreakable connection?}, url = {http://dx.doi.org/10.1111/j.1365-2796.2005.01580.x}, volume = 259, year = 2006 }