%0 Journal Article %1 Baldridge1992 %A Baldridge, G. D. %A Dalton, M. W. %A Fallon, A. M. %D 1992 %J J Mol Evol %K Acid Aedes, Animals; Base Conformation; DNA, Data; Molecular Nucleic Phylogeny; RNA, Ribosomal, Sequence Sequence; Species Specificity genetics; %N 6 %P 514--523 %T Is higher-order structure conserved in eukaryotic ribosomal DNA intergenic spacers? %V 35 %X Computer-based structural analysis of the ribosomal DNA intergenic spacer (IGS) from the mosquito Aedes albopictus revealed a potential to form strong and extensive secondary structures throughout a 4.7-kilobase (kb) region. The predicted stability of secondary structures was particularly high within a 3.15-kb region containing 17 tandem 201 base-pair subrepeats. Similarly strong secondary structure potential was also found when IGS subrepeats were analyzed from 17 phylogenetically diverse eukaryotes, including vertebrates, invertebrates, and plants. Conservation of higher-order structure potential in the IGS region of ribosomal DNA may reflect evolutionary and functional constraints on chromatin organization, transcriptional regulation of the ribosomal RNA genes, and/or transcript processing and stability.

@article{Baldridge1992, __markedentry = {[mdalton]}, abstract = {Computer-based structural analysis of the ribosomal DNA intergenic spacer (IGS) from the mosquito Aedes albopictus revealed a potential to form strong and extensive secondary structures throughout a 4.7-kilobase (kb) region. The predicted stability of secondary structures was particularly high within a 3.15-kb region containing 17 tandem 201 base-pair subrepeats. Similarly strong secondary structure potential was also found when IGS subrepeats were analyzed from 17 phylogenetically diverse eukaryotes, including vertebrates, invertebrates, and plants. Conservation of higher-order structure potential in the IGS region of ribosomal DNA may reflect evolutionary and functional constraints on chromatin organization, transcriptional regulation of the ribosomal RNA genes, and/or transcript processing and stability.}, added-at = {2010-06-02T20:45:31.000+0200}, author = {Baldridge, G. D. and Dalton, M. W. and Fallon, A. M.}, biburl = {https://www.bibsonomy.org/bibtex/20f0533f67f7f83d7891eb6e59d2ee7be/markwdalton}, description = {Marks Publications}, institution = {Department of Entomology, University of Minnesota, St. Paul 55108.}, interhash = {7c6c231235e6c5ab4b76d321bc413d84}, intrahash = {0f0533f67f7f83d7891eb6e59d2ee7be}, journal = {J Mol Evol}, keywords = {Acid Aedes, Animals; Base Conformation; DNA, Data; Molecular Nucleic Phylogeny; RNA, Ribosomal, Sequence Sequence; Species Specificity genetics;}, language = {eng}, medline-pst = {ppublish}, month = Dec, number = 6, owner = {mdalton}, pages = {514--523}, pmid = {1474605}, timestamp = {2010-06-02T20:45:31.000+0200}, title = {Is higher-order structure conserved in eukaryotic ribosomal DNA intergenic spacers?}, volume = 35, year = 1992 }