%0 Journal Article %1 Faivre.2007 %A Faivre, S. %A Demetri, G. %A Sargent, W. %A Raymond, E. %D 2007 %J Nat.Rev.Drug Discov. %K & A Angiogenesis Animals Carcinoma Clinical Design Drug Endothelial Factor France Growth Humans Indoles Inhibitors Kinase Kinases Neoplasm Neoplasms Protein-Tyrosine Pyrroles Receptors Resistance Topic Trials Tyrosine Vascular adverse antagonists as biosynthesis blood drug effects enzymology inhibitors metabolism pharmacology response supply therapeutic therapy use %N 9 %P 734-745 %T Molecular basis for sunitinib efficacy and future clinical development %U PM:17690708 %V 6 %X Sunitinib malate (SU11248/Sutent; Pfizer) is a multitargeted tyrosine kinase inhibitor that has potent anti-angiogenic and antitumour activities. Definitive efficacy has been demonstrated in advanced renal cell carcinoma and in gastrointestinal stromal tumours that are refractory or intolerant to imatinib (Gleevec; Novartis), which has provided the basis for the recent regulatory approvals for these indications. This article summarizes the discovery and development of sunitinib, and discusses key issues for the multitargeted approach in cancer treatment, such as markers of response and development of resistance, and their significance for the future development of sunitinib and other multikinase inhibitors

@article{Faivre.2007, abstract = {Sunitinib malate (SU11248/Sutent; Pfizer) is a multitargeted tyrosine kinase inhibitor that has potent anti-angiogenic and antitumour activities. Definitive efficacy has been demonstrated in advanced renal cell carcinoma and in gastrointestinal stromal tumours that are refractory or intolerant to imatinib (Gleevec; Novartis), which has provided the basis for the recent regulatory approvals for these indications. This article summarizes the discovery and development of sunitinib, and discusses key issues for the multitargeted approach in cancer treatment, such as markers of response and development of resistance, and their significance for the future development of sunitinib and other multikinase inhibitors}, added-at = {2010-02-05T11:28:39.000+0100}, author = {Faivre, S. and Demetri, G. and Sargent, W. and Raymond, E.}, biburl = {https://www.bibsonomy.org/bibtex/253e1171b8a15a9f6bacf8979fae3a8bb/kanefendt}, interhash = {7f08da290ccbebae9c55a097cef1c87a}, intrahash = {53e1171b8a15a9f6bacf8979fae3a8bb}, journal = {Nat.Rev.Drug Discov.}, keywords = {& A Angiogenesis Animals Carcinoma Clinical Design Drug Endothelial Factor France Growth Humans Indoles Inhibitors Kinase Kinases Neoplasm Neoplasms Protein-Tyrosine Pyrroles Receptors Resistance Topic Trials Tyrosine Vascular adverse antagonists as biosynthesis blood drug effects enzymology inhibitors metabolism pharmacology response supply therapeutic therapy use}, number = 9, pages = {734-745}, timestamp = {2010-02-05T11:28:55.000+0100}, title = {Molecular basis for sunitinib efficacy and future clinical development}, url = {PM:17690708}, volume = 6, year = 2007 }