Article,

Severe pyomyositis caused by Panton-Valentine leucocidin-positive methicillin-sensitive Staphylococcus aureus complicating a pilonidal cyst

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Langenbeck's Archives of Surgery / Deutsche Gesellschaft Für Chirurgie, 392 (6): 761--765 (November 2007)PMID: 17661075.
DOI: 10.1007/s00423-007-0212-3

Abstract

\textlessAbstractText Label="BACKGROUND" NlmCategory="BACKGROUND"\textgreaterTo our best knowledge, Panton-Valentine leucocidin (PVL)-positive methicillin-sensitive Staphylococcus aureus (MSSA) has not been described yet as cause for severe pyomyositis.\textless/AbstractText\textgreater \textlessAbstractText Label="CASE REPORT" NlmCategory="METHODS"\textgreaterWe present a 23-year-old apparently healthy male patient without any typical predisposing findings who developed severe pyomyositis secondary to an operated pilonidal cyst. In the follow-up, the patient showed signs of immunocompromisation. The causative agent for purulent infection of multiple muscles was a MSSA strain harbouring PVL toxin.\textless/AbstractText\textgreater \textlessAbstractText Label="RESULTS" NlmCategory="RESULTS"\textgreaterIn the reported case, aggressive antibiotic and surgical treatment with additional application of immunoglobulins has lead to recovery from the disease without relapse.\textless/AbstractText\textgreater \textlessAbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS"\textgreaterPVL-positive S. aureus are associated with skin diseases, multiple abscesses and often complicated by severe sepsis and necrotising pneumonia. Under such circumstances, the mortality rate can reach up to 75\%. In addition, the PVL toxin can cause immunocompromisation and might be therefore involved in the aetiology of pyomyositis. Aggressive antibiotic and surgical treatment with additional application of immunoglobulins is recommended for treatment.\textless/AbstractText\textgreater

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