%0 Journal Article %1 RN47 %A Aliaga, A.E. %A Aguayo, T. %A Garrido, C. %A Clavijo, E. %A Hevia, E. %A Gomez-Jeria, J.S. %A Leyton, P. %A Campos-Vallette, M.M. %A Sanchez-Cortes, S. %D 2011 %I 2010 Wiley Periodicals, Inc. %J Biopolymers %K acids, adedrda, and approximations arginine, aromatic-hydrocarbons, beta-ctp, beta-subunit calculations, carboxy chorionic dqcauchile gonadotropin, hartree-fock hcg human l-lysine, lgrgisl, molecular-orbital mrkdv, of oligopeptides peptide polycyclic prepared raman raman, scattering, sers, silver spectroscopy, surface, surface-enhanced terminal theoretical theories, type, %N 2 %P 135-143 %R 10.1002/bip.21542 %T Surface-Enhanced Raman Scattering and Theoretical Studies of the C-Terminal Peptide of the Beta-Subunit Human Chorionic Gonadotropin without Linked Carbohydrates %U /brokenurl#<Go to ISI>://WOS:000284716500007 %V 95 %X Raman and surface-enhanced Raman scattering (SERS) spectra of the synthetic carboxy terminal peptide of human chorionic gonadatropin beta-subunit free of carbohydrate moieties (P37) are reported. The spectral analysis is performed on the basis of our reported Raman spectrum and SERS data of oligopeptides displaying selected amino acids sequences MRKDV, ADEDRDA, and LGRGISL. SERS samples of P37 were prepared by coating the solid peptide with metal colloids on a quartz slide. This treatment makes possible to obtain high spectral batch to batch reproducibility. Amino acids components of P37 display net charges and hydrophobic characteristics, which are related to particular structural aspects of the adsorbate-substrate interaction. The spectroscopic results are supported by quantum chemical calculations performed by using extended Huckel theory method for a model of P37 interacting with an Ag surface. The P37-metal interaction is drove by positively charged fragments of selected amino acids, mainly threonine 109, lysine 122, and arginine in positions 114 and 133. Data here reported intend to contribute to the knowledge about the antigen-antibody interaction and to the drugs delivery research area.

@article{RN47, abstract = {Raman and surface-enhanced Raman scattering (SERS) spectra of the synthetic carboxy terminal peptide of human chorionic gonadatropin beta-subunit free of carbohydrate moieties (P37) are reported. The spectral analysis is performed on the basis of our reported Raman spectrum and SERS data of oligopeptides displaying selected amino acids sequences MRKDV, ADEDRDA, and LGRGISL. SERS samples of P37 were prepared by coating the solid peptide with metal colloids on a quartz slide. This treatment makes possible to obtain high spectral batch to batch reproducibility. Amino acids components of P37 display net charges and hydrophobic characteristics, which are related to particular structural aspects of the adsorbate-substrate interaction. The spectroscopic results are supported by quantum chemical calculations performed by using extended Huckel theory method for a model of P37 interacting with an Ag surface. The P37-metal interaction is drove by positively charged fragments of selected amino acids, mainly threonine 109, lysine 122, and arginine in positions 114 and 133. Data here reported intend to contribute to the knowledge about the antigen-antibody interaction and to the drugs delivery research area. }, added-at = {2019-12-04T03:57:35.000+0100}, author = {Aliaga, A.E. and Aguayo, T. and Garrido, C. and Clavijo, E. and Hevia, E. and Gomez-Jeria, J.S. and Leyton, P. and Campos-Vallette, M.M. and Sanchez-Cortes, S.}, biburl = {https://www.bibsonomy.org/bibtex/2de1eae450a5addc5519401a000f48795/dqcauchile}, doi = {10.1002/bip.21542}, interhash = {8752d332218e86f66c0c946aa7e62813}, intrahash = {de1eae450a5addc5519401a000f48795}, issn = {0006-3525}, journal = {Biopolymers}, keywords = {acids, adedrda, and approximations arginine, aromatic-hydrocarbons, beta-ctp, beta-subunit calculations, carboxy chorionic dqcauchile gonadotropin, hartree-fock hcg human l-lysine, lgrgisl, molecular-orbital mrkdv, of oligopeptides peptide polycyclic prepared raman raman, scattering, sers, silver spectroscopy, surface, surface-enhanced terminal theoretical theories, type,}, number = 2, pages = {135-143}, publisher = {2010 Wiley Periodicals, Inc.}, timestamp = {2019-12-04T03:58:17.000+0100}, title = {Surface-Enhanced Raman Scattering and Theoretical Studies of the C-Terminal Peptide of the Beta-Subunit Human Chorionic Gonadotropin without Linked Carbohydrates}, type = {Journal Article}, url = {/brokenurl#<Go to ISI>://WOS:000284716500007}, volume = 95, year = 2011 }