%0 Journal Article %1 CatherineA._Macken08151989 %A Macken, Catherine A. %A Perelson, Alan S. %D 1989 %J Proceedings of the National Academy of Sciences %K block_model fitness_landscapes %N 16 %P 6191-6195 %R 10.1073/pnas.86.16.6191 %T Protein Evolution on Rugged Landscapes %U http://www.pnas.org/cgi/content/abstract/86/16/6191 %V 86 %X We analyze a mathematical model of protein evolution in which the evolutionary process is viewed as hill-climbing on a random fitness landscape. In studying the structure of such landscapes, we note that a large number of local optima exist, and we calculate the time and number of mutational changes until a protein gets trapped at a local optimum. Such a hill-climbing process may underlie the evolution of antibody molecules by somatic hypermutation.

@article{CatherineA._Macken08151989, abstract = {We analyze a mathematical model of protein evolution in which the evolutionary process is viewed as hill-climbing on a random fitness landscape. In studying the structure of such landscapes, we note that a large number of local optima exist, and we calculate the time and number of mutational changes until a protein gets trapped at a local optimum. Such a hill-climbing process may underlie the evolution of antibody molecules by somatic hypermutation. }, added-at = {2008-04-20T03:05:53.000+0200}, author = {Macken, Catherine A. and Perelson, Alan S.}, biburl = {https://www.bibsonomy.org/bibtex/20535efb89f95b3ccc1ebabc844fa9dcd/peter.ralph}, description = {Protein Evolution on Rugged Landscapes -- Macken and Perelson 86 (16): 6191 -- Proceedings of the National Academy of Sciences}, doi = {10.1073/pnas.86.16.6191}, eprint = {http://www.pnas.org/cgi/reprint/86/16/6191.pdf}, interhash = {8790507e01711dbdc9a14e781d18b9df}, intrahash = {0535efb89f95b3ccc1ebabc844fa9dcd}, journal = {Proceedings of the National Academy of Sciences}, keywords = {block_model fitness_landscapes}, number = 16, pages = {6191-6195}, timestamp = {2008-04-20T03:05:53.000+0200}, title = {{Protein Evolution on Rugged Landscapes}}, url = {http://www.pnas.org/cgi/content/abstract/86/16/6191}, volume = 86, year = 1989 }