Abstract
The availability of several millions of point mutational differences
between closely related species enabled us to construct the species
specific evolutionary models. Two classes of mutational transitions
were the subject of our analyzes: single nucleotide mutational
replacements and insertion - deletion events, which are caused by the
replication slippage mechanism. Both kinds of mutational changes were
studied separately for protein coding regions and for non-coding
regions. We found that in the period since the last common ancestor to
human and chimpanzee the single nucleotide replacements in human
lineage were not balanced and the principle of detailed balance was
not fulfilled. The matrix of point mutational probabilities 1 was
constructed separately for protein coding and non-coding regions. It
was found that in human lineage the transitions which are replacing
purines with purines or pyrimidines with pyrimidines are increasing
the C+G content of human genome while transversions have the opposite
effect. \\
1) BORSTNIK Branko, PUMPERNIK Danilo, Evidence on DNA
slippage step-length distribution, Phys. Rev. E 71 (2005) 031913
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