Zusammenfassung
In this work we report the synthesis of the complexes of the type
Cu(mu-Cl)\Ph2P(CH2)(n)PPh2C(H)C(O) PhR\(2) (n = 1: R = Cl (1), NO2
(2); n = 2: R = Cl (3), NO2 (4)) derived from the reactions of the
copper(I) chloride with related phosphorus ylides in equimolar ratios
using dry methanol as solvent. The identity of complex 1 was
unequivocally determined by single crystal X-ray diffraction techniques,
its structure consisting of five-membered rings formed by coordination
of the ligands through the phosphine group and the ylidic carbon atom to
the metal center. The coordination geometry around the Cu atoms in this
complex can be defined as slightly distorted tetrahedral.
Characterization of the obtained compounds was also performed by IR,
H-1, P-31 and C-13 NMR spectroscopy and analytical data indicated a 1: 1
stoichiometry between the Cu(I) chloride and ylide. Well-defined
phosphine bis-ylide Cu(I) complexes 1 and 3 were found to be an
effective catalyst for the Suzuki coupling of various aryl halides
including with 4-ethyl phenylboronic acid, giving the desired coupling
products at low catalyst loading in moderate to good yields. Also, the
antibacterial activities of DMSO-solved complexes were measured by disc
diffusion method against 6 Gram positive and negative bacteria. All
Cu(I) complexes exhibited antibacterial activities against bacteria
tested especially Gram negative ones. (C) 2014 Elsevier B.V. All rights
reserved.
Nutzer