%0 Journal Article %1 D0RA04025H %A Hifnawy, Mohamed S. %A Fouda, Mohamed M. %A Sayed, Ahmed M. %A Mohammed, Rabab %A Hassan, Hossam M. %A AbouZid, Sameh F. %A Rateb, Mostafa E. %A Keller, Alexander %A Adamek, Martina %A Ziemert, Nadine %A Abdelmohsen, Usama Ramadan %D 2020 %I The Royal Society of Chemistry %J Royal Society of Chemistry Advances %K alexanderkeller cctb mbd myown %N 35 %P 20939-20959 %R 10.1039/D0RA04025H %T The genus Micromonospora as a model microorganism for bioactive natural product discovery %U http://dx.doi.org/10.1039/D0RA04025H %V 10 %X This review covers the development of the genus Micromonospora as a model for natural product research and the timeline of discovery progress from the classical bioassay-guided approaches through the application of genome mining and genetic engineering techniques that target specific products. It focuses on the reported chemical structures along with their biological activities and the synthetic and biosynthetic studies they have inspired. This survey summarizes the extraordinary biosynthetic diversity that can emerge from a widely distributed actinomycete genus and supports future efforts to explore under-explored species in the search for novel natural products.

@article{D0RA04025H, abstract = {This review covers the development of the genus Micromonospora as a model for natural product research and the timeline of discovery progress from the classical bioassay-guided approaches through the application of genome mining and genetic engineering techniques that target specific products. It focuses on the reported chemical structures along with their biological activities and the synthetic and biosynthetic studies they have inspired. This survey summarizes the extraordinary biosynthetic diversity that can emerge from a widely distributed actinomycete genus and supports future efforts to explore under-explored species in the search for novel natural products.}, added-at = {2020-07-23T15:51:09.000+0200}, author = {Hifnawy, Mohamed S. and Fouda, Mohamed M. and Sayed, Ahmed M. and Mohammed, Rabab and Hassan, Hossam M. and AbouZid, Sameh F. and Rateb, Mostafa E. and Keller, Alexander and Adamek, Martina and Ziemert, Nadine and Abdelmohsen, Usama Ramadan}, biburl = {https://www.bibsonomy.org/bibtex/2d8c017386a19fb745bae3e18bf2f76ce/a.keller81}, doi = {10.1039/D0RA04025H}, interhash = {936e142d609632de870052b688f3eab7}, intrahash = {d8c017386a19fb745bae3e18bf2f76ce}, journal = {Royal Society of Chemistry Advances}, keywords = {alexanderkeller cctb mbd myown}, number = 35, pages = {20939-20959}, publisher = {The Royal Society of Chemistry}, timestamp = {2020-12-16T23:13:52.000+0100}, title = {The genus Micromonospora as a model microorganism for bioactive natural product discovery}, url = {http://dx.doi.org/10.1039/D0RA04025H}, volume = 10, year = 2020 }