%0 Journal Article %1 enard2010human %A Enard, David %A Depaulis, Frantz %A Crollius, Hugues Roest %D 2010 %I Public Library of Science %J PLoS Genet %K hotspots human_chimp popgen selection %N 2 %P e1000840 %R 10.1371/journal.pgen.1000840 %T Human and Non-Human Primate Genomes Share Hotspots of Positive Selection %U http://dx.doi.org/10.1371%2Fjournal.pgen.1000840 %V 6 %X <title>Author Summary</title> <p>An advantageous mutation spreads from generation to generation in a population until individuals that carry it, because of their higher reproductive success, completely replace those that do not. This process, commonly known as positive Darwinian selection, requires the selected mutation to induce a new non-neutral heritable phenotypic trait, and this has been shown to occur unexpectedly frequently during recent human evolution. Although the exact advantageous mutation is difficult to identify, it leaves a wider footprint on neighbouring linked neutral variation called a selective sweep. We have developed an empirical method that uses whole-genome shotgun sequences of single individuals to detect selective sweeps. By doing so, we were able to extend to chimpanzee, orangutan, and macaque individuals analyses of recent positive selection that until now were only available for human. Comparisons of genes candidates for positive selection between human and non-human primates then revealed an unexpectedly high number of cases where a selective sweep at a gene in humans is mirrored by independent positive selection at the same gene in multiple other primates. This result has future implications for understanding the nature of biological changes that underlie selective sweeps in humans.</p>

@article{enard2010human, abstract = {<title>Author Summary</title> <p>An advantageous mutation spreads from generation to generation in a population until individuals that carry it, because of their higher reproductive success, completely replace those that do not. This process, commonly known as positive Darwinian selection, requires the selected mutation to induce a new non-neutral heritable phenotypic trait, and this has been shown to occur unexpectedly frequently during recent human evolution. Although the exact advantageous mutation is difficult to identify, it leaves a wider footprint on neighbouring linked neutral variation called a selective sweep. We have developed an empirical method that uses whole-genome shotgun sequences of single individuals to detect selective sweeps. By doing so, we were able to extend to chimpanzee, orangutan, and macaque individuals analyses of recent positive selection that until now were only available for human. Comparisons of genes candidates for positive selection between human and non-human primates then revealed an unexpectedly high number of cases where a selective sweep at a gene in humans is mirrored by independent positive selection at the same gene in multiple other primates. This result has future implications for understanding the nature of biological changes that underlie selective sweeps in humans.</p> }, added-at = {2010-02-10T18:21:29.000+0100}, author = {Enard, David and Depaulis, Frantz and Crollius, Hugues Roest}, biburl = {https://www.bibsonomy.org/bibtex/2746b3cdb4f8b61524c2d6c724fc5f721/peter.ralph}, doi = {10.1371/journal.pgen.1000840}, interhash = {97e6d63ae856bede561e09625de1668e}, intrahash = {746b3cdb4f8b61524c2d6c724fc5f721}, journal = {PLoS Genet}, keywords = {hotspots human_chimp popgen selection}, month = {02}, number = 2, pages = {e1000840}, publisher = {Public Library of Science}, timestamp = {2010-02-10T18:21:29.000+0100}, title = {Human and Non-Human Primate Genomes Share Hotspots of Positive Selection}, url = {http://dx.doi.org/10.1371%2Fjournal.pgen.1000840}, volume = 6, year = 2010 }