%0 Journal Article %1 livermore_beta-lactamases_1995 %A Livermore, D M %D 1995 %J Clinical Microbiology Reviews %K Bacteria Bacteria, Enterobacteriaceae, Resistance, {Gram-Negative} {Gram-Positive} {beta-Lactamases,} {beta-Lactam} %N 4 %P 557--584 %T beta-Lactamases in laboratory and clinical resistance %U http://www.ncbi.nlm.nih.gov/pubmed/8665470 %V 8 %X beta-Lactamases are the commonest single cause of bacterial resistance to beta-lactam antibiotics. Numerous chromosomal and plasmid-mediated types are known and may be classified by their sequences or phenotypic properties. The ability of a beta-lactamase to cause resistance varies with its activity, quantity, and cellular location and, for gram-negative organisms, the permeability of the producer strain. beta-Lactamases sometimes cause obvious resistance to substrate drugs in routine tests; often, however, these enzymes reduce susceptibility without causing resistance at current, pharmacologically chosen breakpoints. This review considers the ability of the prevalent beta-lactamases to cause resistance to widely used beta-lactams, whether resistance is accurately reflected in routine tests, and the extent to which the antibiogram for an organism can be used to predict the type of beta-lactamase that it produces.

@article{livermore_beta-lactamases_1995, abstract = {{beta-Lactamases} are the commonest single cause of bacterial resistance to beta-lactam antibiotics. Numerous chromosomal and plasmid-mediated types are known and may be classified by their sequences or phenotypic properties. The ability of a beta-lactamase to cause resistance varies with its activity, quantity, and cellular location and, for gram-negative organisms, the permeability of the producer strain. {beta-Lactamases} sometimes cause obvious resistance to substrate drugs in routine tests; often, however, these enzymes reduce susceptibility without causing resistance at current, pharmacologically chosen breakpoints. This review considers the ability of the prevalent beta-lactamases to cause resistance to widely used beta-lactams, whether resistance is accurately reflected in routine tests, and the extent to which the antibiogram for an organism can be used to predict the type of beta-lactamase that it produces.}, added-at = {2011-03-11T10:05:34.000+0100}, author = {Livermore, D M}, biburl = {https://www.bibsonomy.org/bibtex/23976dbe00692f867935433ae38326086/jelias}, interhash = {a48266856544ed7e7999eb69a9cd6e9f}, intrahash = {3976dbe00692f867935433ae38326086}, issn = {0893-8512}, journal = {Clinical Microbiology Reviews}, keywords = {Bacteria Bacteria, Enterobacteriaceae, Resistance, {Gram-Negative} {Gram-Positive} {beta-Lactamases,} {beta-Lactam}}, month = oct, note = {{PMID:} 8665470}, number = 4, pages = {557--584}, timestamp = {2011-03-11T10:05:54.000+0100}, title = {{beta-Lactamases} in laboratory and clinical resistance}, url = {http://www.ncbi.nlm.nih.gov/pubmed/8665470}, volume = 8, year = 1995 }