%0 Journal Article %1 Davatzikos2003 %A Davatzikos, C. %A Barzi, A. %A Lawrie, T. %A Hoon, A. H. %A Melhem, E. R. %D 2003 %J Neuropediatrics %K Adolescent; Cerebral Palsy; Chi; Child, Preschool; Cognition Disorders; Corpus Callosum; Humans; Infant; Infant, Newborn; Leukomalacia, Periventricular; Magnetic Resonance Imaging; Male; Motor Skills Neuropsychological Tests; Severity of Illness Index; ld %N 5 %P 247--252 %R 10.1055/s-2003-43259 %T Correlation of corpus callosal morphometry with cognitive and motor function in periventricular leukomalacia. %U http://dx.doi.org/10.1055/s-2003-43259 %V 34 %X PURPOSE: We aim to correlate size and shape of corpus callosum with severity of motor and cognitive impairments in children with periventricular leukomalacia (PVL). METHODS: Children with PVL were stratified based on the severity of their motor and cognitive impairments. An age-matched control group was established. The corpus callosum was identified on mid-sagittal T (1)-weighted spin-echo (TR/TE: 550/15) MR images. The shape characteristics of the corpus callosum were measured with respect to a template via a shape transformation. The degree of callosal-shape transformation was quantified by a deformation function, which in turn was compared, using point-wise T-tests, for controls versus patients, diplegic versus quadriplegic patients, and patients with mild versus severe cognitive impairment. RESULTS: 29 children with spastic cerebral palsy and PVL and 32 age-matched controls were identified. In the PVL group, the entire corpus callosum was significantly smaller than in the control group (p value = 0.001). Significant differences existed in the shape of the corpus callosum between patients with diplegic versus quadriplegic and between patients with severe versus mild cognitive impairment. CONCLUSION: Global and regional corpus callosal morphology can be quantified using deformation functions.

@article{Davatzikos2003, abstract = {PURPOSE: We aim to correlate size and shape of corpus callosum with severity of motor and cognitive impairments in children with periventricular leukomalacia (PVL). METHODS: Children with PVL were stratified based on the severity of their motor and cognitive impairments. An age-matched control group was established. The corpus callosum was identified on mid-sagittal T (1)-weighted spin-echo (TR/TE: 550/15) MR images. The shape characteristics of the corpus callosum were measured with respect to a template via a shape transformation. The degree of callosal-shape transformation was quantified by a deformation function, which in turn was compared, using point-wise T-tests, for controls versus patients, diplegic versus quadriplegic patients, and patients with mild versus severe cognitive impairment. RESULTS: 29 children with spastic cerebral palsy and PVL and 32 age-matched controls were identified. In the PVL group, the entire corpus callosum was significantly smaller than in the control group (p value = 0.001). Significant differences existed in the shape of the corpus callosum between patients with diplegic versus quadriplegic and between patients with severe versus mild cognitive impairment. CONCLUSION: Global and regional corpus callosal morphology can be quantified using deformation functions.}, added-at = {2014-07-19T19:17:45.000+0200}, author = {Davatzikos, C. and Barzi, A. and Lawrie, T. and Hoon, A. H. and Melhem, E. R.}, biburl = {https://www.bibsonomy.org/bibtex/2216e79180d20b56043c22a2be32beac1/ar0berts}, doi = {10.1055/s-2003-43259}, groups = {public}, interhash = {add1fe31de80074e9f9f9a201245c941}, intrahash = {216e79180d20b56043c22a2be32beac1}, journal = {Neuropediatrics}, keywords = {Adolescent; Cerebral Palsy; Chi; Child, Preschool; Cognition Disorders; Corpus Callosum; Humans; Infant; Infant, Newborn; Leukomalacia, Periventricular; Magnetic Resonance Imaging; Male; Motor Skills Neuropsychological Tests; Severity of Illness Index; ld}, month = Jun, number = 5, pages = {247--252}, pmid = {14598230}, timestamp = {2014-07-19T19:17:45.000+0200}, title = {Correlation of corpus callosal morphometry with cognitive and motor function in periventricular leukomalacia.}, url = {http://dx.doi.org/10.1055/s-2003-43259}, username = {ar0berts}, volume = 34, year = 2003 }