%0 Journal Article %1 Jussila.2002 %A Jussila, L. %A Alitalo, K. %D 2002 %J Physiol Rev. %K A Animals Cells Endothelial Endothelium Factor Factors Growth Humans Laboratories Lymphangiogenesis Lymphatic Lymphedema Lymphokines Metastasis Research System Vascular Vessels blood cells diagnosis embryology physiology physiopathology response %N 3 %P 673-700 %T Vascular growth factors and lymphangiogenesis %U PM:12087132 %V 82 %X Blood and lymphatic vessels develop in a parallel, but independent manner, and together form the circulatory system allowing the passage of fluid and delivering molecules within the body. Although the lymphatic vessels were discovered already 300 years ago, at the same time as the blood circulation was described, the lymphatic system has remained relatively neglected until recently. This is in part due to the difficulties in recognizing these vessels in tissues because of a lack of specific markers. Over the past few years, several molecules expressed specifically in the lymphatic endothelial cells have been characterized, and knowledge about the lymphatic system has started to accumulate again. The vascular endothelial growth factor (VEGF) family of growth factors and receptors is involved in the development and growth of the vascular endothelial system. Two of its family members, VEGF-C and VEGF-D, regulate the lymphatic endothelial cells via their receptor VEGFR-3. With the aid of t

@article{Jussila.2002, abstract = {Blood and lymphatic vessels develop in a parallel, but independent manner, and together form the circulatory system allowing the passage of fluid and delivering molecules within the body. Although the lymphatic vessels were discovered already 300 years ago, at the same time as the blood circulation was described, the lymphatic system has remained relatively neglected until recently. This is in part due to the difficulties in recognizing these vessels in tissues because of a lack of specific markers. Over the past few years, several molecules expressed specifically in the lymphatic endothelial cells have been characterized, and knowledge about the lymphatic system has started to accumulate again. The vascular endothelial growth factor (VEGF) family of growth factors and receptors is involved in the development and growth of the vascular endothelial system. Two of its family members, VEGF-C and VEGF-D, regulate the lymphatic endothelial cells via their receptor VEGFR-3. With the aid of t}, added-at = {2010-02-05T11:28:39.000+0100}, author = {Jussila, L. and Alitalo, K.}, biburl = {https://www.bibsonomy.org/bibtex/2e4b0a66f07e835dc0db92f6682fcc9c6/kanefendt}, interhash = {c40631c481abddd0e3b0ad7f08c45732}, intrahash = {e4b0a66f07e835dc0db92f6682fcc9c6}, journal = {Physiol Rev.}, keywords = {A Animals Cells Endothelial Endothelium Factor Factors Growth Humans Laboratories Lymphangiogenesis Lymphatic Lymphedema Lymphokines Metastasis Research System Vascular Vessels blood cells diagnosis embryology physiology physiopathology response}, number = 3, pages = {673-700}, timestamp = {2010-02-05T11:28:41.000+0100}, title = {Vascular growth factors and lymphangiogenesis}, url = {PM:12087132}, volume = 82, year = 2002 }