A robust infrastructure for solving time-dependent diffusion using
the finite element package FEtk has been developed to simulate synaptic
transmission in a neuromuscular junction with realistic postsynaptic
folds. Simplified rectilinear synapse models serve as benchmarks
in initial numerical studies of how variations in geometry and kinetics
relate to endplate currents associated with fast-twitch, slow-twitch,
and dystrophic muscles. The flexibility and scalability of FEtk affords
increasingly realistic and complex models that can be formed in concert
with expanding experimental understanding from electron microscopy.
Ultimately, such models may provide useful insight on the functional
implications of controlled changes in processes, suggesting therapies
for neuromuscular diseases.