%0 Journal Article %1 Hajishengallis:2012fk %A Hajishengallis, George %A Lambris, John D. %D 2012 %K imported %N 11 %P 1111--1116 %R 10.1016/j.imbio.2012.07.007 %T Complement and dysbiosis in periodontal disease. %U http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22964237&retmode=ref&cmd=prlinks %V 217 %X Signaling crosstalk between complement and Toll-like receptors (TLRs) normally serves to coordinate host immunity. However, the periodontal bacterium Porphyromonas gingivalis expresses C5 convertase-like enzymatic activity and adeptly exploits complement-TLR crosstalk to subvert host defenses and escape elimination. Intriguingly, this defective immune surveillance leads to the remodeling of the periodontal microbiota to a dysbiotic state that causes inflammatory periodontitis. Understanding the mechanisms by which P. gingivalis modulates complement function to cause dysbiosis offers new targets for complement therapeutics.

@article{Hajishengallis:2012fk, abstract = {Signaling crosstalk between complement and Toll-like receptors (TLRs) normally serves to coordinate host immunity. However, the periodontal bacterium Porphyromonas gingivalis expresses C5 convertase-like enzymatic activity and adeptly exploits complement-TLR crosstalk to subvert host defenses and escape elimination. Intriguingly, this defective immune surveillance leads to the remodeling of the periodontal microbiota to a dysbiotic state that causes inflammatory periodontitis. Understanding the mechanisms by which P. gingivalis modulates complement function to cause dysbiosis offers new targets for complement therapeutics.}, added-at = {2017-12-08T05:18:19.000+0100}, affiliation = {University of Pennsylvania School of Dental Medicine, Department of Microbiology, Philadelphia, PA 19104, USA. geoh@upenn.edu}, author = {Hajishengallis, George and Lambris, John D.}, biburl = {https://www.bibsonomy.org/bibtex/2923ffdfd0ee456b8d26d53c264d4f35c/lambris}, date-added = {2016-04-23T19:09:44GMT}, date-modified = {2017-12-08T04:17:04GMT}, doi = {10.1016/j.imbio.2012.07.007}, interhash = {db62e8fad9589163ebec09c15acdb472}, intrahash = {923ffdfd0ee456b8d26d53c264d4f35c}, keywords = {imported}, language = {English}, month = nov, number = 11, pages = {1111--1116}, pmcid = {PMC3439646}, pmid = {22964237}, rating = {0}, timestamp = {2017-12-08T05:18:19.000+0100}, title = {{Complement and dysbiosis in periodontal disease.}}, uri = {\url{papers3://publication/doi/10.1016/j.imbio.2012.07.007}}, url = {http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22964237&retmode=ref&cmd=prlinks}, volume = 217, year = 2012 }