%0 Journal Article %1 zarantonelli_hyperinvasive_2008 %A Zarantonelli, M L %A Lancellotti, M %A Deghmane, A E %A Giorgini, D %A Hong, E %A Ruckly, C %A Alonso, J-M %A Taha, M-K %D 2008 %J Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases %K Animals, Apoptosis, C, Cells, Epithelial Female, France, Genetic Genotype, Humans, Inbred Infections, Meningococcal Mice, Neisseria Variation, Virulence meningitidis, {BALB} %N 5 %P 467--72 %R 10.1111/j.1469-0691.2008.01955.x %T Hyperinvasive genotypes of Neisseria meningitidis in France %U http://www.ncbi.nlm.nih.gov/pubmed/18294240 %V 14 %X Clinical isolates of Neisseria meningitidis from cases of meningococcal disease, collected between January 2000 and December 2004, were identified and typed at the French National Reference Centre. A representative subset of 546 isolates from among 2882 isolates was further genotyped by multilocus sequence typing to determine their genetic lineages (clonal complexes) and the degree of diversification among different clonal complexes. Representative isolates of the main clonal complexes were tested for their virulence in mice and for proapoptotic effects on human epithelial cells. High genetic diversity in some genetic lineages (ST-32 and ST-41/44) was correlated with heterogeneity in virulence in mice and proapoptotic effects on human epithelial cells. In contrast, the homogeneous genetic structure of isolates of the ST-11 clonal complex, regardless of their serogroup, correlated positively with a fatal outcome of the infection, increased virulence in mice and increased proapoptotic effects on human epithelial cells.

@article{zarantonelli_hyperinvasive_2008, abstract = {Clinical isolates of Neisseria meningitidis from cases of meningococcal disease, collected between January 2000 and December 2004, were identified and typed at the French National Reference Centre. A representative subset of 546 isolates from among 2882 isolates was further genotyped by multilocus sequence typing to determine their genetic lineages (clonal complexes) and the degree of diversification among different clonal complexes. Representative isolates of the main clonal complexes were tested for their virulence in mice and for proapoptotic effects on human epithelial cells. High genetic diversity in some genetic lineages {(ST-32} and {ST-41/44)} was correlated with heterogeneity in virulence in mice and proapoptotic effects on human epithelial cells. In contrast, the homogeneous genetic structure of isolates of the {ST-11} clonal complex, regardless of their serogroup, correlated positively with a fatal outcome of the infection, increased virulence in mice and increased proapoptotic effects on human epithelial cells.}, added-at = {2011-03-11T10:05:34.000+0100}, author = {Zarantonelli, M L and Lancellotti, M and Deghmane, A E and Giorgini, D and Hong, E and Ruckly, C and Alonso, {J-M} and Taha, {M-K}}, biburl = {https://www.bibsonomy.org/bibtex/299467ea12f72eb55c6969c7f8b296191/jelias}, doi = {10.1111/j.1469-0691.2008.01955.x}, interhash = {e820812822c80bfa60e45b62d07abb95}, intrahash = {99467ea12f72eb55c6969c7f8b296191}, issn = {{1198-743X}}, journal = {Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases}, keywords = {Animals, Apoptosis, C, Cells, Epithelial Female, France, Genetic Genotype, Humans, Inbred Infections, Meningococcal Mice, Neisseria Variation, Virulence meningitidis, {BALB}}, month = may, note = {{PMID:} 18294240}, number = 5, pages = {467--72}, timestamp = {2011-03-11T10:06:38.000+0100}, title = {Hyperinvasive genotypes of Neisseria meningitidis in France}, url = {http://www.ncbi.nlm.nih.gov/pubmed/18294240}, volume = 14, year = 2008 }